环境污染物引发不明病因流产的新途径和新机制  

New pathways and mechanisms of unexplained miscarriage induced by environmental pollutants

作　　者：林晏冰 孙义 张慧东 Lin Yanbing;Sun Yi;Zhang Huidong*(The Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen 518033,Guangdong,China)

机构地区：[1]中山大学附属第八医院,广东深圳518033

出　　处：《生物医学转化》2025年第1期43-49,共7页Biomedical Transformation

基　　金：国家自然科学基金项目(82073589,82373602)。

摘　　要：环境污染物可能是导致不明病因流产的重要风险因素。研究发现多种环境污染物,如多环芳烃、纳米塑料、金属物质、缺氧环境和自来水消毒副产物等,均与不明病因流产相关。本文致力于探讨环境污染物导致滋养层细胞功能障碍引发的不明病因流产的调控机制和干预措施,为保护女性生殖健康提供了重要的科学依据。Environmental pollutants may be an important risk factor for unexplained miscarriage.Studies have shown that various environmental pollutants,such as polycyclic aromatic hydrocarbons,nanoplastics,metallic substances,hypoxic conditions,and disinfection by-products in tap water,are associated with unexplained miscarriage.This study aims to explore the regulatory mechanisms and intervention measures of trophoblast cell dysfunction induced by environmental pollutants that leads to unexplained miscarriage,thereby providing important scientific evidence for protecting women's reproductive health.

关 键 词：不明病因流产 环境污染物 多环芳烃 纳米塑料 缺氧 消毒副产物 

分 类 号：R114[医药卫生—卫生毒理学]