儿童神经发育障碍疾病的环境病因识别  

Identification of environmental etiologies of neurodevelopmental disorders in children

作　　者：李媛媛[1] Li Yuanyuan(School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)

机构地区：[1]华中科技大学同济医学院公共卫生学院,湖北武汉430030

出　　处：《生物医学转化》2025年第1期58-61,共4页Biomedical Transformation

基　　金：国家自然科学基金项目(U23A20493)。

摘　　要：儿童神经发育障碍(NDDs)是由多种遗传性或者获得性病因导致的一类慢性发育性脑功能障碍疾病,致残率高,大部分缺乏有效的治疗手段。NDDs病因复杂,普遍认为由遗传和环境因素共同作用所致。识别NDDs的环境病因对控制NDDs风险有重要意义。本文综述了近年NDDs的环境病因识别方面的研究进展,介绍了以流行病学为基础和以毒理学为基础的环境病因筛查方法,探讨了各类方法的优势与缺陷,并对未来的发展进行了展望。Neurodevelopmental disorders(NDDs)are a group of chronic developmental brain dysfunctions caused by various genetic or acquired factors,characterized by high disability rates and a lack of effective treatments.The etiology of NDDs is highly complex,and it is widely believed that it arises from the interaction of genetic and environmental factors.Identifying environmental risk factors for NDDs is crucial for risk control and prevention.This review summarizes recent advancements in the identification of environmental etiologies of NDDs,introduces epidemiology-based and toxicology-based screening methods,discusses their advantages and limitations,and provides insights into future development.

关 键 词：神经发育障碍 环境病因 暴露组学 系统毒理学 化学品筛选技术 

分 类 号：R114[医药卫生—卫生毒理学]