“真实世界暴露”的生殖发育毒理学综合研究策略:从人群流行病学到体内和体外实验  

Integrated research strategies for reproductive and developmental toxicology of real-world exposure:Integrating population epidemiology with in vivo and in vitro experiments

作　　者：程千慧 李赛男 王琳琳[1] Cheng Qianhui;Li Sainan;Wang Linlin(Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health(School of Public Health,Peking University),Department of Epidemiology and Biostatistics,School of Public Health,Peking University,State Key Laboratory of Female Fertility Promotion,Peking University,Beijing 100191,China)

机构地区：[1]北京大学生育健康研究所/国家卫生健康委生育健康重点实验室(北京大学公共卫生学院),北京大学公共卫生学院流行病与卫生统计学系,北京大学女性生育力促进全国重点实验室,北京100191

出　　处：《生物医学转化》2025年第1期78-86,共9页Biomedical Transformation

基　　金：国家重点研发计划项目(2022YFC2705205);国家自然科学基金面上项目(82473639)。

摘　　要：人类在真实世界中长期、低剂量地暴露于数量庞大且成分复杂的化学混合物,这种暴露可能对健康,尤其是生殖发育健康,造成潜在威胁。因此,理解真实世界暴露,即化学混合物在环境水平的暴露对健康的影响及其作用机制至关重要。这需要整合人群流行病学数据与体内、体外毒理学研究,构建针对环境水平化学混合物暴露的真实世界暴露健康效应综合研究框架。本文系统阐述了真实世界暴露健康效应研究的最新进展,重点介绍了几种适用于体内和体外毒理学实验的化学混合物识别与确定方法,并综述了这些策略在生殖发育毒理学研究中的应用。相关研究为完善真实世界暴露健康效应的综合研究框架奠定了基础,并为更精准的生殖发育健康风险评估和干预策略提供了科学依据。Humans are continuously exposed to large numbers of complex chemical mixtures at low doses in real-world environments,which may pose potential threats to health,particularly to reproductive and developmental health.Therefore,understanding real-world exposure—specifically,the effects of chemical mixtures at environmental concentrations on health and their underlying mechanisms—is crucial.This requires integrating population epidemiological data with in vivo and in vitro toxicological studies to establish an integrated research framework for assessing the health effects of real-world exposure to chemical mixtures at environmental concentrations.This review systematically examines recent advancements in evaluating the health effects of real-world chemical exposure,with a particular focus on methodologies for identifying and characterizing chemical mixtures suitable for in vivo and in vitro toxicological experiments.Additionally,it reviews the application of these strategies in reproductive and developmental toxicology research.These studies lay the foundation for refining an integrated research framework for real-world exposure health effects and provide scientific evidence for more precise reproductive and developmental health risk assessment and intervention strategies.

关 键 词：真实世界暴露 化学混合物 环境水平 生殖毒理 发育毒理 

分 类 号：R114[医药卫生—卫生毒理学]