盐酸氨溴索联合哌拉西林钠他唑巴坦钠治疗老年重症肺炎患者的效果  

Effects of Ambroxol hydrochloride combined with Piperacillin sodium and Tazobactam sodium in treatment of elderly patients with severe pneumonia

作　　者：裴艳兵 PEI Yanbing(Department of Respiratory Medicine of Yanling Hospital,Xuchang 461200 Henan,China)

机构地区：[1]鄢陵医院呼吸内科,河南许昌461200

出　　处：《中国民康医学》2025年第6期22-25,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察盐酸氨溴索联合哌拉西林钠他唑巴坦钠治疗老年重症肺炎患者的效果。方法:选取2022年1月至2024年1月该院收治的78例老年重症肺炎患者进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各39例。对照组采用哌拉西林钠他唑巴坦钠治疗,观察组在对照组基础上联合盐酸氨溴索治疗。比较两组临床疗效,临床症状(肺部湿啰音、肺部水肿、咳嗽及气促)消失时间,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、呼气流量峰值(PEF)]、炎性因子[血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]、T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平,以及不良反应发生率。结果:观察组治疗总有效率为92.31%(36/39),高于对照组的74.36%(29/39),差异有统计学意义(P<0.05);观察组肺部湿啰音、肺部水肿、咳嗽、气促等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、FVC、PEF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、IL-8、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,两组CD8^(+)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸氨溴索联合哌拉西林钠他唑巴坦钠治疗老年重症肺炎患者可提高治疗总有效率和肺功能指标水平,改善血气分析指标和T细胞亚群指标水平,以及降低炎性因子水平,效果优于单纯哌拉西林钠他唑巴坦钠治疗。Objective:To observe effects of Ambroxol hydrochloride combined with Piperacillin sodium and Tazobactam sodium in treatment of elderly patients with severe pneumonia.Methods:A prospective study was conducted on 78 elderly patients with severe pneumonia admitted to this hospital from January 2022 to January 2024.According to the random number table method,they were divided into control group and observation group,39 cases in each group.The control group was treated with Piperacillin sodium and Tazobactam sodium,while the observation group was treated with Ambroxol hydrochloride on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(lung wet rales,pulmonary edema,cough and shortness of breath),the levels of pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF)],the levels of inflammatory factors[serum tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)]and the levels of T cell subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.31%(36/39),which was higher than 74.36%(29/39)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of lung wet rales,lung edema,cough,shortness of breath and other symptoms in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV_(1),FVC and PEF in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,IL-8 and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the di

关 键 词：老年 重症肺炎 氨溴索 哌拉西林钠他唑巴坦钠 肺功能 炎性因子 T细胞亚群 

分 类 号：R563.1[医药卫生—呼吸系统]