粒细胞集落刺激因子宫腔灌注联合常规药物治疗反复种植失败患者的效果  

Effects of granulocyte colony-stimulating factor intrauterine infusion combined with conventional drugs in treatment of patients with repeated implantation failure

作　　者：付静文 张富青[1] 刘敏[1] 苏丽霄[1] FU Jingwen;ZHANG Fuqing;LIU Min;SU Lixiao(Department of Reproductive Genetics of Women&Infants Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市妇幼保健院生殖遗传科,河南郑州450000

出　　处：《中国民康医学》2025年第6期61-63,67,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察粒细胞集落刺激因子宫腔灌注联合常规药物治疗反复种植失败(RIF)患者的效果。方法:回顾性分析2022-2023年该院收治的123例RIF患者的临床资料,根据治疗方法不同将其分为对照组61例和观察组62例。对照组采用常规药物治疗,观察组在对照组基础上联合粒细胞集落刺激因子宫腔灌注治疗。比较两组治疗前后子宫内膜厚度、子宫动脉血流参数[搏动指数(PI)、阻力指数(RI)]水平、性激素(雌二醇、孕酮)水平、子宫内膜形态类型,以及临床妊娠率。结果:治疗后,两组子宫内膜厚度均大于治疗前,且观察组大于对照组,两组PI、RI水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组雌二醇、孕酮水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,观察组A型子宫内膜率高于对照组,C型子宫内膜率低于对照组,差异均有统计学意义(P<0.05),两组B型子宫内膜率比较,差异无统计学意义(P>0.05);观察组临床妊娠率高于对照组,差异有统计学意义(P<0.05)。结论:粒细胞集落刺激因子宫腔灌注联合常规药物治疗RIF患者可增大子宫内膜厚度,降低子宫动脉血流参数水平,提高性激素水平和临床妊娠率,改善子宫内膜形态类型,效果优于单纯常规药物治疗。Objective:To observe effects of granulocyte colony-stimulating factor intrauterine infusion combined with conventional drugs in treatment of patients with repeated implantation failure(RIF).Methods:The clinical data of 123 patients with RIF admitted to this hospital from 2022 to 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(61 cases)and observation group(62 cases).The control group was treated with conventional drugs,while the observation group was treated with granulocyte colony-stimulating factor intrauterine infusion on the basis of that of the control group.The endometrial thickness,the levels of uterine artery blood flow parameters[pulsatility index(PI),resistance index(RI)]and sex hormones(estradiol,progesterone),the endometrial morphological types before and after the treatment,and the clinical pregnancy rates were compared between the two groups.Results:After the treatment,the endometrial thickness levels of the two groups were greater than those before the treatment,and that in the observation group was greater than that in the control group;the levels of PI and RI in the two groups were lower than those before the treatment,and those in the observation group was lower than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of estradiol and progesterone in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the type A endometrial rate in the observation group was higher than that in the control group,the type C endometrial rate was lower than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the type B endometrial rate between the two groups(P>0.05).The clinical pregnancy rate of the observation group was higher than that of the control group,

关 键 词：反复种植失败 粒细胞集落刺激因子 宫腔灌注 子宫内膜 子宫动脉血流参数 性激素 妊娠率 

分 类 号：R71[医药卫生—妇产科学]