香丹注射液联合阿司匹林与氯吡格雷治疗急性心肌梗死经皮冠状动脉介入治疗术后患者的效果  

Effects of Xiangdan injection combined with Aspirin and Clopidogrel in treatment of patients with acute myocardial infarction after percutaneous coronary intervention

作　　者：王小玮 WANG Xiaowei(Department of Cardiovascular Medicine of Qinyang Hospital of Traditional Chinese Medicine,Jiaozuo 454550 Henan,China)

机构地区：[1]沁阳市中医院心血管内科,河南焦作454550

出　　处：《中国民康医学》2025年第6期90-92,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察香丹注射液联合阿司匹林与氯吡格雷治疗急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后患者的效果。方法:回顾性分析2021年7月至2023年12月该院收治的60例AMI患者的临床资料,按照治疗方法不同将其分为对照组与观察组各30例。对照组给予阿司匹林与氯吡格雷治疗,观察组在对照组基础上联合香丹注射液治疗。比较两组治疗前后心肌损伤标志物[肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)、脑利尿钠肽(BNP)]水平、超敏C反应蛋白(hs-CRP)水平,以及不良反应发生率和再灌注损伤发生率。结果:治疗后,两组CK-MB、cTnⅠ、BNP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组hs-CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组再灌注损伤发生率低于对照组,差异有统计学意义(P<0.05)。结论:香丹注射液联合阿司匹林与氯吡格雷治疗AMI PCI术后患者可降低心肌损伤标志物水平、hs-CRP水平和再灌注损伤发生率,效果优于阿司匹林与氯吡格雷治疗。Objective:To observe effects of Xiangdan injection combined with Aspirin and Clopidogrel in treatment of patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:The clinical data of 60 patients with AMI admitted to this hospital from July 2021 to December 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,30 cases in each group.The control group was treated with Aspirin and Clopidogrel,while the observation group was treated with Xiangdan injection on the basis of that of the control group.The levels of myocardial injury markers[creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),brain natriuretic peptide(BNP)]and high-sensitivity C-reactive protein(hs-CRP),the incidence of adverse reactions,and the incidence of reperfusion injury were compared between the two groups before and after the treatment.Results:After the treatment,the levels of CK-MB,cTnI and BNP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of hs-CRP in the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).During the treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of reperfusion injury in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusions:Xiangdan injection combined with Aspirin and Clopidogrel can reduce the levels of myocardial injury markers and hs-CRP and the incidence of reperfusion injury in the patients with AMI after PCI.Moreover,it is superior to Aspirin and Clopidogrel treatment.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 香丹注射液 阿司匹林 氯吡格雷 再灌注损伤 

分 类 号：R542.2[医药卫生—心血管疾病]