丹参酮ⅡA磺酸钠注射液联合常规西药治疗冠心病心绞痛患者的效果  

Effects of Sulfotanshinone sodium injection combined with conventional Western medicine in treatment of patients with angina pectoris and coronary heart disease

作　　者：王晨 WANG Chen(Department of Pharmacy of Shangqiu Central Hospital,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市中心医院药剂科,河南商丘476000

出　　处：《中国民康医学》2025年第6期93-95,118,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察丹参酮ⅡA磺酸钠注射液联合常规西药治疗冠心病心绞痛患者的效果。方法:回顾性分析2022年1月至2023年12月该院收治的105例冠心病心绞痛患者的临床资料,按治疗方案不同分为对照组(n=51)、观察组(n=54)。对照组采用常规西药(富马酸比索洛尔片、阿托伐他汀钙片、阿司匹林肠溶片)治疗,观察组在对照组基础上联合丹参酮ⅡA磺酸钠注射液治疗,比较两组治疗总有效率、心绞痛发作频率、每次发作持续时间、心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]水平、血液流变学指标[血浆黏度、全血高切黏度(HS)、全血低切黏度(LS)、纤维蛋白原(FIB)、血细胞比容(HCT)、红细胞沉降率(ESR)]水平、血管内皮功能指标[内皮素-1(ET-1)、血管生成素样蛋白2(ANGPTL2)]水平和不良反应发生率。结果:观察组治疗总有效率为94.44%,明显高于对照组的80.39%,差异有统计学意义(P<0.05);治疗后,观察组LVEF水平高于对照组,心绞痛发作频率、LVEDD、HS、血浆黏度、LS及FIB、HCT、ESR、ET-1、ANGPTL2水平低于对照组,每次发作持续时间短于对照组,差异均有统计学意义(P<0.05);两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丹参酮ⅡA磺酸钠注射液联合常规西药治疗冠心病心绞痛患者可提高治疗总有效率,改善其心功能指标水平,缩短其每次发作持续时间,降低其心绞痛发作频率、血液流变学指标水平、血管内皮功能指标水平,效果优于单纯常规西药治疗。Objective:To observe effects of Sulfotanshinone sodium injection combined with conventional Western medicine in treatment of patients with angina pectoris and coronary heart disease.Methods:The clinical data of 105 patients with coronary heart disease and angina pectoris admitted to this hospital from January 2022 to December 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group(n=51)and observation group(n=54).The control group was treated with conventional Western medicine(Bisoprolol fumarate tablets,Atorvastatin calcium tablets,Aspirin enteric-coated tablets),while the observation group was treated with Sulfotanshinone sodium injection on the basis of that of the control group.The total effective rate,the frequency of angina pectoris attack,the duration of each attack,the levels of cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],hemorheology indexes[plasma viscosity,whole blood high shear viscosity(HS),whole blood low shear viscosity(LS),fibrinogen(FIB),hematocrit(HCT),erythrocyte sedimentation rate(ESR)]and vascular endothelial function indexes[endothelin-1(ET-1),angiopoietin-like protein 2(ANGPTL2)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.44%,which was significantly higher than 80.39%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the LVEF level in the observation group was higher than that in the control group;the frequency of angina pectoris and the levels of LVEDD,HS,plasma viscosity,LS,FIB,HCT,ESR,ET-1 and ANGPTL2 were lower than those in the control group;the duration of each attack was shorter than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05).Conclusions:Sulfot

关 键 词：冠心病 心绞痛 丹参酮ⅡA磺酸钠注射液 心功能 血液流变学 血管内皮功能 不良反应 

分 类 号：R541.4[医药卫生—心血管疾病]