热毒宁注射液联合阿奇霉素治疗肺炎支原体肺炎痰热壅肺证患儿的效果  

Effects of Reduning injection combined with Azithromycin in treatment of mycoplasma pneumoniae pneumonia with phlegm-heat obstructing lung syndrome

作　　者：李晓娟[1] LI Xiaojuan(Department of Pediatrics of Anyang People’s Hospital,Anyang 455000 Henan,China)

机构地区：[1]安阳市人民医院儿科,河南安阳455000

出　　处：《中国民康医学》2025年第6期99-102,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察热毒宁注射液联合阿奇霉素治疗肺炎支原体肺炎痰热壅肺证患儿的效果。方法:选取2022年1月至2024年1月该院收治的120例肺炎支原体肺炎患儿进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各60例。对照组采用阿奇霉素治疗,研究组在对照组基础上联合热毒宁注射液治疗。比较两组临床疗效,临床症状(咳嗽、发热、肺啰音)消失时间,治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、每分钟最大通气量(MVV)]、炎性指标[C反应蛋白(CRP)、中性粒细胞]、T细胞亚群指标(CD3+、CD4+、CD8+)水平,以及不良反应发生率。结果:研究组治疗总有效率为88.33%(53/60),高于对照组的71.67%(43/60),差异有统计学意义(P<0.05);研究组咳嗽、发热、肺啰音消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV1、FVC、MVV水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、中性粒细胞水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD3+、CD4+水平均高于治疗前,且研究组高于对照组,两组CD8+水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:热毒宁注射液联合阿奇霉素治疗肺炎支原体肺炎痰热壅肺证患儿可提高治疗总有效率和肺功能指标水平,缩短临床症状消失时间,改善T细胞亚群指标水平,以及降低炎性指标水平,效果优于单纯阿奇霉素治疗。Objective:To observe effects of Reduning injection combined with Azithromycin in treatment of mycoplasma pneumoniae pneumonia with phlegm-heat obstructing lung syndrome.Methods:A prospective study was conducted on 120 children with mycoplasma pneumoniae pneumonia admitted to this hospital from January 2022 to January 2024.They were divided into control group and study group according to the random number table method,60 cases each.The control group was treated with Azithromycin,while the study group was treated with Reduning injection on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(cough,fever,lung rales),the levels of lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),maximum ventilation volume per minute(MVV)]and inflammatory indexes[C-reactive protein(CRP),neutrophils],T cell subsets indexes(CD3+,CD4+,CD8+)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 88.33%(53/60),which was higher than 71.67%(43/60)in the control group,and the difference was statistically significant(P<0.05).The disappearance time of cough,fever and pulmonary rales in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and MVV in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and neutrophils in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD3+and CD4+in the two groups were higher than those before the treatment,and those in the study group were higher than those i

关 键 词：热毒宁注射液 阿奇霉素注射液 肺炎支原体肺炎 痰热壅肺证 肺功能 炎性 

分 类 号：R725.6[医药卫生—儿科]