芪归通络颗粒治疗糖尿病周围神经病变患者的疗效及应用价值  

Therapeutic efficacy and application value of Qigui Tongluo Granules in the treatment of patients with diabetic peripheral neuropathy

作　　者：申泽民 阚全娥[2] 魏卓恒 SHEN Zemin;KAN Quan'e;WEI Zhuoheng(Department of Endocrinology,Linzhou People's Hospital,Linzhou 456550,China;Department of Endocrinology,Henan Provincial People's Hospital,Zhengzhou 450000,China)

机构地区：[1]林州市人民医院内分泌科,河南林州456550 [2]河南省人民医院内分泌科,河南郑州450000

出　　处：《黑龙江医药科学》2025年第3期43-46,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关联合共建项目,编号:LHGJ20218722。

摘　　要：目的:观察芪归通络颗粒联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效及其应用价值。方法:回顾性选取2022年1月至2023年8月林州市人民医院收治的80例DPN患者,依据治疗方案分为单一组(n=40)、联合组(n=40)。单一组予以甲钴胺治疗,联合组予以芪归通络颗粒+甲钴胺治疗,连续治疗4周。治疗4周后对比两组临床疗效及治疗前后中医证候积分、神经电生理指标[感觉传导速度(SCV)、运动传导速度(MCV)]、炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[超氧化物歧化酶(SOD)、γ-谷氨酰转肽酶(GGT)、丙二醛(MDA)]。比较两组不良反应。结果:联合组总有效率高于单一组(90.00%vs 72.50%,P<0.05);联合组治疗后中医证候积分低于单一组(P<0.05);与单一组比较,联合组治疗后正中神经SCV、腓浅神经SCV、正中神经MCV、腓总神经MCV升高(P<0.05);与单一组比较,联合组治疗后血清hs-CRP、IL-6、TNF-α水平降低(P<0.05);与单一组比较,联合组治疗后血清SOD水平升高,GGT、MDA水平降低(P<0.05);两组治疗期间无明显药物不良反应。结论:芪归通络颗粒联合甲钴胺治疗DPN的疗效显著,可改善临床症状、神经电生理,抑制炎症反应,提高机体抗氧化能力,且具有一定安全性。Objective:To observe the clinical efficacy and application value of Qigui Tongluo Granules combined with Mecobalamin in the treatment of diabetic peripheral neuropathy(DPN).Methods:A retrospective analysis was conducted on 80 patients with DPN from Linzhou People's Hospital between January 2022 and August 2023.The patients were divided into monotherapy group(n=40)and combination therapy group(n=40)based on their treatment regimens.The monotherapy group received Mecobalamin treatment,while the combination therapy group received Qigui Tongluo Granules plus Mecobalamin for 4 consecutive weeks.After 4 weeks of treatment,comparisons were made between the two groups in terms of clinical efficacy,Traditional Chinese Medicine(TCM)syndrome scores,neuroelectrophysiological indicators[sensory conduction velocity(SCV)and motor conduction velocity(MCV)],inflammatory cytokines[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)],and oxidative stress indicators[superoxide dismutase(SOD),γ-glutamyltransferase(GGT)and malondialdehyde(MDA)]before and after treatment.Adverse reactions were also compared between the two groups.Results:The total effective rate in the combination therapy group was higher than that in the monotherapy group(90.00%vs 72.50%,P<0.05).After treatment,the TCM syndrome scores in the combination therapy group were lower than those in the monotherapy group(P<0.05).Compared with the monotherapy group,the SCV of the median nerve,SCV of the superficial peroneal nerve,MCV of the median nerve and MCV of the common peroneal nerve increased in the combination therapy group after treatment(P<0.05).Additionally,compared with the monotherapy group,the levels of serum hs-CRP,IL-6 and TNF-αdecreased in the combination therapy group after treatment(P<0.05).Furthermore,compared with the monotherapy group,the serum SOD level increased,while the levels of GGT and MDA decreased in the combination therapy group after treatment(P<0.05).There were no significant adverse drug reacti

关 键 词：糖尿病周围神经病变 甲钴胺 芪归通络颗粒 神经电生理 疗效 

分 类 号：R255.4[医药卫生—中医内科学]