阿托伐他汀钙辅助常规用药对高血压肾病患者炎症因子及动脉血压的影响  

Effect of atorvastatin calcium combined with conventional medication on inflammatory factors and arterial blood pressure in patients with hypertensive nephropathy

作　　者：樊新成 张将军 张慧敏 FAN Xincheng;ZHANG Jiangjun;ZHANG Huimin(Department of Nephrology,Xiangcheng Traditional Chinese Medicine Hospital,Xiangcheng 466200,China)

机构地区：[1]项城市中医院肾病科,河南项城466200

出　　处：《黑龙江医药科学》2025年第3期99-102,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省自然科学基金项目,编号:20220291。

摘　　要：目的:探究高血压肾病患者采用阿托伐他汀钙辅助常规用药的临床疗效。方法:选取2022年6月至2024年2月项城市中医院收治的120例高血压肾病患者,依据随机数字表法分组,每组60例。对照组:常规治疗;观察组:常规治疗+阿托伐他汀钙治疗,对比两组相关指标。结果:观察组治疗后炎症因子水平较对照组低(P<0.05);两组治疗后血管内皮功能对比有差异(P<0.05);观察组治疗后动脉血压、肾功能较对照组低(P<0.05)。结论:在对高血压肾病患者治疗时,阿托伐他汀钙可凸显较好的治疗效果,可缓解炎症反应,有效控制血压。Objective:To explore the clinical efficacy of atorvastatin calcium in assisting conventional medication for patients with hypertensive nephropathy.Methods:120 patients with hypertensive nephropathy from Xiangcheng Traditional Chinese Medicine Hospital from June 2022 to February 2024 were selected for in-depth analysis.They were randomly divided into control group(routine treatment)and observation group(routine treatment+atorvastatin calcium treatment)based on a random number table method,with 60 cases in each group.The inflammatory and arterial blood pressure between the two groups of patients were compared.Results:The levels of inflammatory factors in observation group were lower than those in control group after treatment(P<0.05);There was a significant difference in vascular endothelial function between the two groups after treatment(P<0.05);The arterial blood pressure and renal function in observation group were lower than those in control group after treatment(P<0.05).Conclusion:Atorvastatin calcium can highlight better therapeutic effects in the treatment of patients with hypertensive nephropathy,alleviate inflammatory reactions,effectively control blood pressure,and can be promoted.

关 键 词：高血压肾病 阿托伐他汀钙 炎症因子 动脉血压 血管内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病] R255.3[医药卫生—内科学]