基于血清AMPK/mTOR信号通路探讨中西医结合治疗冠心病的作用机制研究  

To Explore the Mechanism of Integrated Traditional Chinese and Western Medicine in the Treatment of Coronary Neart Disease Based on Serum AMPK/mTOR Signaling Pathway

作　　者：秦书彦 吕树志[1] 赵海洋[1] QIN Shuyan;LYU Shuzhi;ZHAO Haiyang(The Second Peoples Hospital of Nanyang,Nanyang 473000,Henan,China)

机构地区：[1]南阳市第二人民医院,河南南阳473000

出　　处：《实用中医内科杂志》2025年第3期97-101,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20210977)。

摘　　要：目的该研究旨在探究中西医结合治疗冠心病时,血清中腺苷酸活化蛋白激酶(AMPK)与哺乳动物雷帕霉素靶蛋白(mTOR)信号通路的作用机理。方法纳入了2022年6月—2024年2月就诊的100例冠心病患者,并随机分为两组:对照组与观察组。对照组实施标准的西医治疗方案,而观察组则在西医基础上辅助以中药方剂治疗。研究将评估两组患者的临床治疗效果、血清生化指标变化,以及AMPK/mTOR信号通路相关蛋白的表达情况,并记录不良反应。结果相较于对照组,观察组的临床疗效显著更优(P<0.05)。治疗后,两组的血清TC、TG、LDL-C、hs-CRP、CK-MB、cTnI均显著降低(P<0.05),而HDL-C则显著升高(P<0.05),且观察组的改善幅度更大(P<0.05)。同时,治疗后两组的p-AMPK/AMPK比值均上升(P<0.05),p-mTOR/mTOR比值均下降(P<0.05),观察组的变动幅度更显著(P<0.05)。不良反应方面,两组间无显著差异(P>0.05)。结论中西医结合治疗冠心病可能通过调控血清AMPK/mTOR信号通路来发挥作用,这为冠心病的治疗策略提供了新的视角与手段。Objective The purpose of this study was to explore the mechanism of action of AMP-activated protein kinase(AMPK)and mammalian target of rapamycin(mTOR)signaling pathway in serum in the treatment of coronary heart disease with integrated traditional Chinese and Western medicine.Methods This study included 100 patients with coronary heart disease who were treated between June 2022 and February 2024 and were randomly divided into two groups:control group and observation group.The control group was treated with standard western medicine,while the observation group was treated with traditional Chinese medicine prescription on the basis of western medicine.The study will evaluate the clinical treatment effect,changes in serum biochemical indicators,and expression of AMPK/mTOR signaling pathway-related proteins in the two groups of patients,and record adverse reactions.Results Compared with the control group,the clinical efficacy of the observation group was significantly better(P<0.05).After treatment,the serum TC,TG,LDL-C,hs-CRP,CK-MB and cTnI of the two groups were significantly decreased(P<0.05),while HDL-C was significantly increased(P<0.05),and the improvement of the observation group was greater(P<0.05).At the same time,the p-AMPK/AMPK ratio of the two groups increased after treatment(P<0.05),and the p-mTOR/mTOR ratio decreased(P<0.05),and the change range of the observation group was more significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of traditional Chinese and Western medicine in the treatment of coronary heart disease may play a role by regulating the serum AMPK/mTOR signaling pathway,which provides a new perspective and means for the treatment strategy of coronary heart disease.

关 键 词：冠心病 中西医结合 AMPK/mTOR信号通路 作用机制 

分 类 号：R541.4[医药卫生—心血管疾病]