表面增强拉曼光谱及其在药学领域的应用  

Surface-enhanced Raman Spectroscopy and Its Pharmaceutical Application

作　　者：路静慧 严菲 黄朝瑜 芦丽 Lu Jinghui;Yan Fei;Huang Chaoyu;Lu Li(Jiangsu Institute for Food and Drug Control,Nanjing 210019,China)

机构地区：[1]江苏省食品药品监督检验研究院,南京210019

出　　处：《广东化工》2025年第3期118-120,共3页Guangdong Chemical Industry

基　　金：江苏省药品监督管理局药品监管科学科研计划项目(202314)。

摘　　要：表面增强拉曼光谱(SERS)技术因其高灵敏度和无需复杂样品制备过程等优势,在药学领域展现出巨大应用潜力。本文综述了SERS技术在药物分析测试领域的最新进展,特别是在非法添加药物检测、中药分析、药物递送系统等方面的应用成果。SERS技术通过其独特的增强机制,能够有效识别和定量微量非法添加药物,为复杂样品中的药物分析提供了新的策略。随着SERS活性基底材料的不断优化和检测技术的改进,预计SERS将在未来的药学研究和实践中发挥更加重要的作用。Surface-enhanced Raman spectroscopy(SERS)has demonstrated significant potential in the pharmaceutical field,thanks to its high sensitivity and the simplicity of sample preparation.This review summarizes the latest developments in the application of SERS technology within the realm of pharmaceutical analysis,particularly in the detection of illicit drug additives,traditional Chinese medicine analysis,and drug delivery systems.Utilizing its distinctive enhancement mechanism,SERS technology can effectively identify and quantify trace amounts of illegal additives,offering a novel strategy for pharmaceutical analysis in complex samples.As SERS-active substrate materials continue to be optimized and detection techniques are refined,it is anticipated that SERS will play an increasingly important role in future pharmaceutical research and clinical practice.

关 键 词：表面增强拉曼光谱 药物分析 非法添加 生物样本 中药 

分 类 号：TQ[化学工程]