联苯苄唑涂膜剂的制备与透皮研究  

Preparation and Transdermal Study of Bifonazole Coating Agent

作　　者：吴启鹏 蔡慧玲 胡佳 吴洁 裴景超 许萌芳 廖如燕 Wu Qipeng;Cai Huiling;Hu Jia;Wu Jie;Pei Jingchao;Xu Mengfang;Liao Ruyan(Guangzhou Medical University,Guangzhou 511495,China;Guangzhou Customs Technology Center,Guangzhou 510623,China)

机构地区：[1]广州医科大学,广东广州511495 [2]广州海关技术中心,广东广州510623

出　　处：《广东化工》2025年第4期26-28,35,共4页Guangdong Chemical Industry

基　　金：广东省防治新冠病毒科技攻关专项(2023A1111040002);海关总署科研项目(2022HK082)。

摘　　要：目的:本文阐述了一种高渗透量的联苯苄唑制剂的制备方法与表征。方法:使用新型的成膜材料制备了联苯苄唑涂膜剂,并使用扩散池法,对自制的长效喷雾与市售的联苯苄唑乳膏进行了透皮的对比。结果:实验结果显示,自制的联苯苄唑涂膜剂能够显著提高联苯苄唑累计渗透量、皮肤滞留量、最大渗透速率。结论:自制的联苯苄唑涂膜剂能够提升药物的疗效,增加患者的顺应性。Objective:This paper describes the preparation and characterization of a bifonazole formulation with high permeation capacity.Methods:A bifonazole spray was prepared using a novel film-forming material,and a comparison of the homemade long-lasting spray with the commercially available bifonazole cream in terms of transdermal permeation was carried out using the diffusion cell method.Results:The experimental results showed that the homemade bifonazole spray was able to significantly increase the cumulative amount of bifonazole penetration,skin retention,and maximum penetration rate.Conclusion:The homemade bifonazole spray was able to enhance the efficacy of the drug and increase patient compliance.

关 键 词：联苯苄唑 涂膜剂 透皮 

分 类 号：R944[医药卫生—药剂学] R96[医药卫生—药学]