倾向性评分匹配法对集中采购注射用头孢哌酮钠舒巴坦钠用于成人肺部感染的疗效与安全性评价  

Efficacy and safety of cefoperazone sodium and sulbactam sodium for injection in adult pulmonary infections using PSM method

作　　者：张宇 吕鹏 李静[1] 张京莉[1] Zhang Yu;Lyu Peng;Li Jing;Zhang Jingli(Department of Pharmacy,Taihe Country People′s Hospital,Taihe Hospital of Wannan Medical College,Anhui 236600,China)

机构地区：[1]安徽省太和县人民医院皖南医学院附属太和医院药剂科,236600

出　　处：《山西医药杂志》2025年第6期403-406,共4页Shanxi Medical Journal

基　　金：国家卫健委医院管理研究所医疗质量(循证)管理研究项目(YLZLXZ24G047);安徽中医药大学非直属附属医院临床科研项目一般项目(2024LCRM06);安徽省阜阳市重点研究与开发计划项目临床医学研究转化专项项目(FK20245523)。

摘　　要：目的利用倾向性评分匹配(PSM)的方法,回顾性分析、比较集中采购前、后注射用头孢哌酮钠舒巴坦钠在治疗肺部感染时的疗效与安全性差异。方法利用我院合理用药检测系统(PASS)系统,抽取我院2023年8月至2024年8月诊断为“肺部感染”的成人患者,根据纳入及排除排标准提取病历信息,最终获得集中采购前注射用头孢哌酮钠舒巴坦钠(2∶1)(1.5 g)的病例137份;集中采购后的注射用头孢哌酮钠舒巴坦钠(1∶1)(1.0 g)的病例142份。以前者为对照组,后者为试验组,以注射用头孢哌酮钠舒巴坦钠的疗效为因变量,利用PSM平衡2组患者的性别、年龄、合并疾病以及合并用药等混杂因素,分析注射用头孢哌酮钠舒巴坦钠的疗效以及不良反应在2组间的差异。结果通过匹配患者性别、年龄以及合并疾病等因素后,集中采购前注射用头孢哌酮钠舒巴坦钠的有效率为93.6%,集中采购后的有效率为92.3%,2组疗效差异无统计学意义(Z=-1.02,P=0.667),长期使用时2组不良反应发生率分别为5.4%、7.7%,组间差异无统计学意义(χ^(2)=2.40,P>0.05)。结论集中采购后注射用头孢哌酮钠舒巴坦钠在治疗肺部感染时疗效与安全性与集中采购前相当。Objective The efficacy and safety differences of cefoperazone sodium and sulbactam sodium for injection before and after collection in the treatment of pulmonary infections was compared and a retrospective analysis was conducted using the propensity score matching(PSM).Methods Adult patients diagnosed with"pulmonary infection"in our hospital from August 2023 to August 2024 were selected by PASS system.Medical record information was extracted according to the inclusion and exclusion criteria,and 137 cases were finally obtained using cefoperazone sodium and sulbactam sodium(2∶1)(1.5 g)for injection before centralized collection;142 cases were treated with injection of cefoperazone sodium and sulbactam sodium(1∶1)(1.0 g)after centralized collection.The former served as the control group,while the latter served as the experimental group.The efficacy of cefoperazone sodium and sulbactam sodium for injection was used as the dependent variable,and PSM was used to balance confounding factors such as gender,age,comorbidities,and concomitant medications between the two groups.The differences in efficacy and adverse reactions of cefoperazone sodium and sulbactam sodium for injection between the two groups were examined.Results After matching factors such as patient gender,age,and comorbidities,the effective rate of injection of cefoperazone sodium and sulbactam sodium before centralized collection was 93.6%,and the effective rate after centralized collection was 92.3%.There was no significant difference in efficacy between the two groups(Z=-1.02,P=0.667),The incidence of adverse reactions in the two groups during long-term use was 5.4%and 7.7%,respectively,with no significant difference between the groups(P>0.05).Conclusion The efficacy and safety of cefoperazone sodium and sulbactam sodium for injection after centralized collection in the treatment of pulmonary infections are comparable to those before centralized collection.

关 键 词：倾向性评分匹配 注射用头孢哌酮钠舒巴坦钠 集采 肺部感染 疗效 安全性 

分 类 号：R47[医药卫生—护理学]