开郁益肾汤加减对伴轻度焦虑、抑郁不孕症患者情绪状态及子宫内膜容受性的影响  

Effects of Kaiyu Yishen Decoction on the emotional state and endometrial receptivity in infertility patients with mild anxiety and depression

作　　者：章文齐 王维 ZHANG Wenqi;WANG Wei(Department of Pharmacy,Ankang Traditional Chinese Medicine Hospital,Ankang 725000,China)

机构地区：[1]安康市中医医院药剂科,安康725000

出　　处：《西北药学杂志》2025年第2期186-193,共8页Northwest Pharmaceutical Journal

基　　金：陕西省中医药管理局科研课题(共建类研究课题)(编号:2019-GJ-LC014)。

摘　　要：目的观察开郁益肾汤加减对伴轻度焦虑、抑郁的不孕症患者情绪状态及子宫内膜容受性的影响。方法将92例伴有轻度焦虑、抑郁的不孕症患者随机分为安慰组(n=46)和开郁益肾组(n=46)。2组均给予健康宣教和心理疏导,在此基础上,安慰组给予安慰剂治疗,开郁益肾组给予开郁益肾汤加减治疗。比较2组的焦虑、抑郁评分、中医症状评分,检测2组绒毛膜促性腺激素(human chorionic gonadotropin,HCG)日子宫内膜厚度、卵泡直径、子宫动脉参数、5羟色胺(5-hydroxytryptamine,5-HT)、P物质(substance P,SP)、性激素水平,记录2组12个月内妊娠率。结果治疗前,2组焦虑、抑郁评分、中医症状评分比较,差异均无统计学意义(P>0.05)。治疗后,2组焦虑、抑郁评分及中医症状评分较治疗前均降低,且开郁益肾组低于安慰组(P<0.05)。治疗前2组HCG日子宫内膜厚度、卵泡直径比较,差异均无统计学意义(P>0.05)。治疗后,2组卵泡直径较治疗前均增大,且开郁益肾组大于安慰组(P<0.05);观察组治疗后HCG日子宫内膜厚度高于治疗前和安慰组(P<0.05)。2组治疗前子宫动脉参数比较,差异无统计学意义(P>0.05)。开郁益肾组治疗后左侧和右侧搏动指数(pulsatility index,PI)、阻力指数(resistive index,RI)、子宫动脉收缩期峰值流速/舒张末期流速比值(uterine artery systolic peak velocity/end-diastolic velocity ratio,S/D)均低于治疗前和安慰组(P<0.05);安慰组治疗前后子宫动脉参数比较,差异无统计学意义(P>0.05)。治疗前2组5-HT、SP、性激素比较,差异均无统计学意义(P>0.05)。治疗后2组5-HT、雌二醇(2-estradiol,E2)、黄体生成素(luteinizing hormone,LH)较治疗前均升高,且开郁益肾组均高于安慰组(P<0.05);2组SP、卵泡刺激素(follicule-stimulating hormone,FSH)较治疗前均降低,且开郁益肾组较安慰组的变化更显著(P<0.05)。开郁益肾组的妊娠率为43.48%,高于安慰组的19.57%,2组比Objective To observe the effects of Kaiyu Yishen Decoction on the emotional state and endometrial receptivity in infertility patients with mild anxiety and depression.Methods Ninety-two infertile patients with mild anxiety and depression were randomly divided into a placebo group(n=46)and a Kaiyu Yishen Decoction group(n=46).Both groups received health education and psychological counseling,the placebo group was administered placebo treatment,while the Kaiyu Yishen Decoction group received Kaiyu Yishen Decoction.The scores of anxiety,depression and traditional Chinese medicine(TCM)symptoms were compared between the 2 groups.Additionally,the endometrial thickness,follicle diameter,uterine artery parameters,the levels of 5-hydroxytryptamine(5-HT),substance P(SP)and sex hormone were detected on chorionic gonadotropin(HCG)days.The pregnancy rate within 12 months was also recorded.Results There was no statistically significant difference in anxiety,depression,and TCM symptom scores between the 2 groups prior to treatment(P>0.05).After treatment,anxiety,depression,and TCM symptom scores decreased in both groups compared with their baseline levels,with the Kaiyu Yishen group showing significantly lower scores than the placebo group(P<0.05).The comparison of endometrial thickness and follicle diameter on the day of HCG administration prior to treatment between the 2 groups revealed no statistically significant difference(P>0.05).Post-treatment,the follicle diameter in both groups increased compared with pre-treatment values,with the Kaiyu Yishen group exhibiting a significantly greater diameter than the placebo group(P<0.05).Additionally,endometrial thickness on the day of HCG was greater in the observation group than both its pre-treatment measurements and those of the placebo group(P<0.05).Prior to treatment,the comparison of uterine artery parameters between the 2 groups showed no statistically significant difference(P>0.05).However,after treatment,the left and right pulsatility index(PI),resistance index(RI),and the

关 键 词：开郁益肾汤 焦虑 抑郁 不孕症 情绪状态 子宫内膜容受性 妊娠 

分 类 号：R971[医药卫生—药品]