纤维化指标-4与老年急性冠脉综合征病人Gensini积分的相关性研究  

Correlation of fibrosis 4 score with Gensini score in elderly patients with acute coronary syndrome

作　　者：任小田 庄德荣 王文苑 蔡定华 高阳 马开阳 REN Xiaotian;ZHUANG Derong;WANG Wenyuan;CAI Dinghua;GAO Yang;MA Kaiyang(Department of Cardiology,Affiliated Jiangdu People’s Hospital of Yangzhou University,Yangzhou 225200,China;Department of Cardiology,Affiliated Hospital of Yangzhou University,Yangzhou 225000,China)

机构地区：[1]扬州大学附属江都人民医院心内科,江苏省扬州市225200 [2]扬州大学附属医院心内科,江苏省扬州市225000

出　　处：《实用老年医学》2025年第3期278-281,共4页Practical Geriatrics

基　　金：扬州市社会发展项目(YZ2023145);扬州市江都人民医院院内科研基金项目(YNKT202209)。

摘　　要：目的探讨纤维化指标-4(FIB-4)与老年急性冠脉综合征(ACS)病人Gensini积分的相关性及其对冠脉严重程度的预测价值。方法纳入146例老年ACS病人,计算Gensini积分,依据中位数分为低分组(≤37分)和高分组(>37分),采用多因素logistic回归分析Gensini积分升高的危险因素。采用ROC曲线分析FIB-4对ACS病人冠脉病变严重程度的预测价值。结果2组间BMI、WBC、中性粒细胞、AST、ALT、TC、UA、LDL-C、甘油三酯葡萄糖(TyG)指数、FIB-4水平及中性粒细胞计数/淋巴细胞计数比值(NLR)差异具有统计学意义。多因素logistic回归分析显示,UA、TyG、FIB-4和NLR是Gensini积分升高的独立危险因素;ROC曲线分析结果表明,FIB-4预测Gensini积分升高的曲线下面积为0.793,高于NLR、TyG和UA。结论FIB-4指数与老年ACS病人Gensini积分之间呈正相关,且可以预测ACS病人冠脉病变的严重程度。Objective To explore the relationship of fibrosis 4 score(FIB-4)with Gensini score in the elderly patients with acute coronary syndrome(ACS).Methods A total of 146 elderly patients with ACS were enrolled in the study,and were divided into the low Gensini group(≤37)and high Gensini group(>37)according to Gensini score.The general data and laboratory indexes were compared between the two groups.Multivariable logistic regression analysis was performed to identify the influencing factors of Gensini score.Receiver operating characteristic curve analysis was used to explore the predictive value of FIB-4 for the severity of coronary artery lesions in the patients with ACS.Results There were statistically significant differences in body mass index(BMI),white blood cell count,neutrophils,aspartate aminotransferase(AST),alanine-aminotransferase(ALT),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),uric acid(UA),Gensini score,triglyceride-glucose index(TyG),FIB-4 and neutrophil-to-lymphocyte ratio(NLR)between the two groups.Multivariate logistic regression analysis showed that UA,TyG,FIB-4 and NLR were independent risk factors for the increase of Gensini score.The area under the curve of FIB-4 in predicting the increase of Gensini score was 0.79,which was higher than that of NLR,TyG and UA alone.Conclusions FIB-4 is positively correlated with Gensini score,and it can be used as economic and easily measured laboratory indicator to predict the severity of ACS in elderly patients.

关 键 词：FIB-4 急性冠脉综合征 GENSINI积分 

分 类 号：R541.3[医药卫生—心血管疾病]