肌肉减少性肥胖和心血管疾病的关系:系统评价和Meta分析  

Relationship between sarcopenic obesity and cardiovascular diseases:a systematic review and Meta-analysis

作　　者：任紫钰 吴妹 郭鹏霞 奥琪 易少威 李行知 周罡[6,7] 李娜 吴建军[1] 马彬 Ren Ziyu;Wu Mei;Guo Pengxia;Ao Qi;Yi Shaowei;Li Xingzhi;Zhou Gang;Li Na;Wu Jianjun;Ma Bin(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China.;不详)

机构地区：[1]甘肃中医药大学公共卫生学院,兰州730000 [2]兰州大学基础医学院/循证医学中心,兰州730000 [3]淄博师范高等专科学校,淄博255130 [4]甘肃省第三人民医院内二科(CCU),兰州730000 [5]新乡医学院第一临床医学院,新乡453000 [6]甘肃省人民医院心内科干部病区,兰州730000 [7]兰州大学第一临床医学院,兰州730000 [8]西北民族大学,兰州730030 [9]兰州大学医疗器械监管研究中心,兰州730000 [10]甘肃省医疗器械循证研究与评价标准行业中心,兰州730000

出　　处：《中国循证心血管医学杂志》2025年第2期145-152,共8页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：甘肃省自然科学基金(5JRRAO46)。

摘　　要：目的肌肉减少性肥胖(以下简称肌少性肥胖,SO)是肥胖与肌少症共存的状态,有研究显示肌少性肥胖会增加老年人群罹患心血管疾病(CVD)的风险,但受限于当前此类研究设计方法以及不同研究对SO的诊断方法不同,目前尚不清楚中老年肌少性肥胖患者是否具有更高的心血管疾病发病风险。方法计算机检索PubMed、EMbase、Web of Science、中国知网、维普、万方数据、CBM数据库中关于SO和CVD的观察性研究,检索时限为建库至2022年11月。由2名研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用STATA 15.0软件进行Meta分析,计算SO患者发生CVD风险的汇总相对比值比(ORs)及95%的置信区间(95%CIs)。结果共纳入11项研究,包含42683例研究对象。Meta分析结果显示:总体而言,SO与CVD事件之间存在显著关联(OR:2.07;95%CI:1.54~2.77)。亚组分析进一步揭示,随着年龄增加,SO患者发生CVD的风险呈上升趋势;SO与冠状动脉疾病的发病风险关联最高;SO不同标准对预测CVD风险存在差异,采用单一检测方法确诊的SO患者中,其CVD的发病风险最高。结论SO与CVD发病风险增加相关,年龄是SO影响CVD的重要危险因素之一,老年人群是当前临床筛查的重点,同时,有必要进一步探讨SO与不同CVD事件,特别是对冠状动脉疾病的影响,进一步探讨SO诊断方法及标准,以促进相关领域的研究,为预防和管理肌少性肥胖相关的心血管风险提供更为精准和有效的策略。Objective To review systematically the relationship between sarcopenic obesity(SO)and cardiovascular diseases(CVD)in elderly patients.Methods The databases of PubMed,EMbase,Web of Science,Wanfang Data,CBM,CNKI,and VIP were retrieved for collecting observational studies on the relationship between SO and CVD from database establishment time to Nov.2022.After screened literature,extracted information and evaluated the risk of bias in included studies by 2 investigators independently,and a Meta-analysis was conducted by using STATA15.0 software.The pooled relative odds ratios(ORs)and 95%confidence internals(95%CIs)of CVD risk were calculated in SO patients.Results There were totally 11 studies included with 42683 study subjects.The results of Meta-analysis showed that generally SO was significantly correlated to CVD(OR=2.07,95%CI:1.54~2.77).The results of subgroup analysis further showed that CVD risk increased as age increasing in SO patients.The correlation between SO and coronary artery disease was the most significant.There were differences among different SO criteria in predicting CVD risk,and CVD risk was the highest in SO patients diagnosed by a single test method.Conclusion SO is correlated to increased CVD risk,and age is one of important risk factors for SO affecting CVD.The elderly population should be the current focus of clinical screening.It is necessary to further explore the influence of SO on different CVD events,especially on coronary artery disease.The diagnostic methodology and criteria of SO should be further investigated,in order to promote researches in related fields,and to provide a more precise and effective strategy for preventing and managing cardiovascular risk correlated to SO.

关 键 词：心血管疾病 肌肉减少性肥胖 系统评价 META分析 

分 类 号：R54[医药卫生—心血管疾病]