左卡尼汀辅助血液透析治疗对慢性肾衰竭患者微炎症状态和毒素清除率的影响  

Effects of Levocarnitine Assisted Hemodialysis on Microinflammatory Status and Toxin Clearance in Patients with Chronic Renal Failure

作　　者：李亚 LI Ya(Nephrology Department,Mudan People's Hospital of Heze City,Heze 274000,China)

机构地区：[1]菏泽市牡丹人民医院肾内科,山东菏泽274000

出　　处：《中国医学创新》2025年第7期1-5,共5页Medical Innovation of China

摘　　要：目的:探究左卡尼汀辅助血液透析治疗慢性肾衰竭(CRF)患者的临床效果及对患者微炎症状态及毒性清除率的影响。方法:选择2017年12月—2022年12月菏泽市牡丹人民医院收治的1031例CRF患者,依据治疗方案差异划分为观察组(n=486)、对照组(n=545)。对照组给予血液透析治疗,观察组给予左卡尼汀辅助血液透析治疗,比较两组临床有效率、肾功能指标、估算肾小球滤过率(eGFR)、内生肌酐清除率(Ccr)、毒素清除率、炎症因子水平。结果:观察组临床总有效率、血磷清除率、血钾清除率、甲状旁腺激素清除率均高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组血肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白定量、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组eGFR、Ccr均高于治疗前,且观察组均高于对照组,差异均有统计学意义(P<0.05)。结论:CRF患者采用左卡尼汀辅助血液透析治疗效果显著,可改善肾功能,提升eGFR、Ccr水平,提高毒素清除率,缓解炎症反应。Objective:To explore the clinical effect of Levocarnitine assisted hemodialysis in the treatment of patients with chronic renal failure(CRF)and its influence on microinflammatory status and toxic clearance.Method:A total of 1,031 patients with CRF treated in Mudan People's Hospital of Heze City from December 2017 to December 2022 were selected and divided into observation group(n=486)and control group(n=545)according to the difference of treatment plans.The control group was given hemodialysis treatment,and the observation group was given Levocarnitine assisted hemodialysis treatment.The clinical effective rate,renal function index,estmate glomerular filtration rate(eGFR),endogenous creatinine clearance(Ccr),toxin clearance and inflammatory factor levels of the two groups were compared.Result:The clinical effective rate,blood phosphorus clearance,blood potassium clearance and parathyroid hormone clearance of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).After treatment,serum creatinine(Scr),blood urea nitrogen(BUN),24 h urinary protein quantity,C reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in two groups were lower than those before treatment,and those in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,eGFR,Ccr in two groups were higher than those before treatment,and those in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Conclusion:Levocarnitine assisted hemodialysis in patients with CRF has significant effects,which can improve renal function,increase eGFR and Ccr levels,increase toxin clearance rate,and alleviate inflammation.

关 键 词：左卡尼汀 血液透析 慢性肾衰竭 

分 类 号：R73[医药卫生—肿瘤]