归脾合剂联合磷酸西格列汀片对2型糖尿病患者血糖水平的影响  

Effect of Guipi Mixture Combined with Sitagliptin Phosphate Tablets on Blood Glucose Level in Type 2 Diabetes Mellitus Patients

作　　者：何美玲 傅晓虎 罗彬 HE Meiling;FU Xiaohu;LUO Bin(Department of Endocrinology,Shangrao Municipal Hospital,Shangrao 334000,China)

机构地区：[1]上饶市立医院内分泌科,江西上饶334000

出　　处：《中国医学创新》2025年第7期40-44,共5页Medical Innovation of China

摘　　要：目的:分析中成药制剂归脾合剂联合磷酸西格列汀片对2型糖尿病患者血糖指标的影响。方法:选取2021年2月—2024年2月在上饶市立医院内分泌科就诊并接受治疗的2型糖尿病患者80例,使用随机数表法分为西格列汀组(磷酸西格列汀片单独治疗)和联合用药组(归脾合剂联合磷酸西格列汀片治疗),各40例。两组均治疗3个月。比较两组中医症状积分、血糖指标水平、胰岛素功能及不良反应发生率。结果:治疗后,两组形体肥胖、烦渴多饮、大便泄泻、肢体困倦等中医症状积分均下降,且联合用药组均低于西格列汀组,差异均有统计学意义(P<0.05);治疗后两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)水平均降低,且联合用药组均低于西格列汀组,差异均有统计学意义(P<0.05);治疗后两组空腹胰岛素(FINS)水平、胰岛素抵抗指数(HOMA-IR)均降低,联合用药组均低于西格列汀组,差异均有统计学意义(P<0.05);联合用药组不良反应发生率(5.00%)与西格列汀组(10.00%)比较差异无统计学意义(P>0.05)。结论:归脾合剂联合磷酸西格列汀片治疗2型糖尿病能有效改善患者中医症状,纠正患者糖代谢紊乱,改善胰岛功能,且具有一定用药安全性。Objective:To analyze the impact of Guipi Mixture in combination with Sitagliptin Phosphate Tablets on the blood glucose levels of type 2 diabetes mellitus patients.Method:A total of 80 patients with type 2 diabetes mellitus who were treated in the Department of Endocrinology of Shangrao Municipal Hospital from February 2021 to February 2024 were selected and divided into Sitagliptin group(Sitagliptin Phosphate Tablets alone)and combined medication group(Guipi Mixture combined with Sitagliptin Phosphate Tablets)by random number table method,with 40 cases in each group.Both groups were treated for 3 months.TCM symptom score,blood glucose index level,insulin function and incidence of adverse reactions were compared between the two groups.Result:After treatment,the scores of traditional Chinese medicine symptoms such as body obesity,polydipsia,stool diarrhea and limb drowsiness decreased in both groups,and those in combined medication group were lower than those in Sitagliptin group,the differences were statistical significance(P<0.05).After treatment,fasting plasma glucose(FPG)level,postprandial 2-hour plasma glucose(2 h PG)level and glycosylated hemoglobin(HbA1c)level were all decreased in both groups,and those of combined medication group were lower than those of Sitagliptin group,the differences were statistical significance(P<0.05).After treatment,fasting insulin(FINS)level and insulin resistance index(HOMA-IR)were decreased in both groups,and those of the combined medication group were lower than those of Sitagliptin group,the differences were statistical significance(P<0.05).The incidence of adverse reaction in the combined medication group(5.00%)was not statistically significantly different compared to the Sitagliptin group(10.00%)(P>0.05).Conclusion:The combination of Guipi Mixture and Sitagliptin Phosphate Tablets can effectively improve the traditional Chinese medicine symptoms and correct the patients'glucose metabolism disorder in the treatment of type 2 diabetes mellitus,as well as improve pancreatic fu

关 键 词：归脾合剂 磷酸西格列汀片 2型糖尿病 血糖水平 

分 类 号：R587.1[医药卫生—内分泌]