湿润烧伤膏联合PRP治疗糖尿病足溃疡的效果  

Effect of Moist Exposed Burn Ointment Combined with PRP on Diabetic Foot Ulcer

作　　者：林传兴 陈建崇 黄家欣 温雪晶 张斌斌 LIN Chuanxing;CHEN Jianchong;HUANG Jiaxin;WEN Xuejing;ZHANG Binbin(Department of Burn and Plastic Surgery,Putian 95 Hospital,Putian 351100,China)

机构地区：[1]莆田九十五医院烧伤整形美容科,福建莆田351100

出　　处：《中国医学创新》2025年第7期60-63,共4页Medical Innovation of China

摘　　要：目的:探究湿润烧伤膏(MEBO)联合自体富血小板血浆(PRP)治疗糖尿病足溃疡(DFU)的效果。方法:选取2021年6月—2024年3月莆田九十五医院收治的96例DFU患者,以随机数字表法分为对照组(n=48)、观察组(n=48),在常规治疗基础上,对照组予以MEBO治疗,观察组予以MEBO联合自体PRP治疗,均治疗1个月,比较两组疗效;于治疗前后,比较两组溃疡面积、实验室指标[超敏C反应蛋白(hs-CRP)、白介素-1(IL-1)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)]。结果:与对照组总有效率(79.17%)比较,观察组总有效率(95.83%)较高,差异有统计学意义(P<0.05);治疗后,两组溃疡面积均缩小,且观察组小于对照组,差异均有统计学意义(P<0.05);治疗后,两组hs-CRP、IL-1水平均下降,VEGF、bFGF水平均升高,且观察组均优于对照组,差异均有统计学意义(P<0.05)。结论:MEBO联合自体PRP治疗DFU可提高效果,缩小溃疡面积,降低炎症因子水平,提高血管内皮细胞功能。Objective:To investigate the efficacy of Moist Exposed Burn Ointment(MEBO)combined with autologous platelet-rich plasma(PRP)in the treatment of diabetic foot ulcer(DFU).Method:A total of 96 DFU patients admitted to Putian 95 Hospital from June 2021 to March 2024 were divided into control group(n=48)and observation group(n=48)by random number table method.In addition to conventional treatment,the control group received MEBO therapy,whereas the observation group underwent a combination therapy of MEBO and autologous PRP.Two groups were treated for 1 month,and the efficacy of the two groups was compared.The ulcer area and laboratory parameters[hypersensitive C reactive protein(hs-CRP),interleukin-1(IL-1),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)]of the two groups were compared before and after treatment.Result:Compared with the total effective rate of the control group(79.17%),the observation group exhibited a higher total effective rate of 95.83%,with a statistically significant difference(P<0.05).After treatment,the ulcer area of the two groups decreased,and that in the observation group was smaller than that in the control group,the difference was statistically significant(P<0.05).Post-treatment,both groups experienced reductions in hs-CRP and IL-1 levels,along with increases in VEGF and bFGF levels,notably,the observation group showed more favorable outcomes compared to the control group,with statistically significant differences(P<0.05).Conclusion:MEBO combined with autologous PRP in the treatment of DFU can improve the therapeutic effect,reduce the ulcer area,reduce the levels of inflammatory factors and improve the function of vascular endothelial cells.

关 键 词：糖尿病足溃疡 湿润烧伤膏 富血小板血浆 创面面积 

分 类 号：R58[医药卫生—内分泌]