NT-proBNP、cTnI水平与非ST段抬高型急性冠脉综合征患者心功能的关系研究  

Study on the Relationship between NT-proBNP,cTnI Levels and Cardiac Function in Patients with Non-ST-segment Elevation Acute Coronary Syndrome

作　　者：刘涛 杜海龙 谢坛林 LIU Tao;DU Hailong;XIE Tanlin(Department of Cardiovascular Medicine,People's Hospital of Ruijin City,Ruijin 342500,China)

机构地区：[1]瑞金市人民医院心血管内科,江西瑞金342500

出　　处：《中国医学创新》2025年第7期113-116,共4页Medical Innovation of China

摘　　要：目的:研究N末端B型利钠肽原(NT-proBNP)和心肌肌钙蛋白I(cTnI)水平与非ST段抬高型急性冠脉综合征(NSTE-ACS)患者心功能的关系。方法:选取2022年3月—2024年2月于瑞金市人民医院心血管内科治疗的102例NSTE-ACS患者作为病例组,另选同期本院健康体检者34例作为对照组。比较所有患者的血清NT-proBNP、cTnI水平,分析NT-proBNP、cTnI与NSTE-ACS患者左心室射血分数(LVEF)的关系。结果:病例组血清NT-proBNP、cTnI水平均高于对照组,差异均有统计学意义(P<0.05)。病例组不同心功能Killip分级患者的血清NT-proBNP、cTnI水平比较,差异均有统计学意义(P<0.05),且KillipⅣ级患者血清NT-proBNP、cTnI水平均高于KillipⅢ级患者,KillipⅢ级患者血清NTproBNP、cTnI水平均高于KillipⅡ级患者,KillipⅡ级患者血清NT-proBNP、cTnI水平均高于KillipⅠ级患者,差异均有统计学意义(P<0.05)。Pearson相关系数分析表明,血清NT-proBNP、cTnI水平和NSTEACS患者的LVEF呈负相关(P<0.05)。结论:NSTE-ACS患者血清NT-proBNP、cTnI水平高于健康者,且心功能Killip分级越高,血清NT-proBNP、cTnI水平越高,NT-proBNP、cTnI与NSTE-ACS患者的LVEF呈负相关。Objective:To investigate the relationship between N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac troponin I(cTnI)levels and cardiac function in patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS).Method:A total of 102 patients with NSTE-ACS who were treated in the Cardiovascular Department of People's Hospital of Ruijin City from March 2022 to February 2024 were selected as the case group,and 34 healthy subjects in our hospital during the same period were selected as the control group.The serum levels of NT-proBNP and cTnI in all patients were compared,and the relationship between NTproBNP,cTnI and left ventricular ejection fraction(LVEF)of patients with NSTE-ACS was analyzed.Result:The levels of serum NT-proBNP and cTnI in case group were higher than those in control group,the differences were statistically significant(P<0.05).The levels of serum NT-proBNP and cTnI in patients with different Killip grades of cardiac function in the case group were statistically significant(P<0.05),and the levels of serum NT-proBNP and cTnI in Killip gradeⅣpatients were higher than those in Killip gradeⅢpatients,the levels of serum NT-proBNP and cTnI in Killip gradeⅢpatients were higher than those in Killip gradeⅡpatients,and the levels of serum NTproBNP and cTnI in Killip gradeⅡpatients were higher than those in Killip gradeⅠpatients,the differences were statistically significant(P<0.05).Pearson correlation coefficient analysis showed that serum NT-proBNP and cTnI levels were negatively correlated with LVEF in NSTE-ACS patients(P<0.05).Conclusion:The levels of serum NTproBNP and cTnI in NSTE-ACS patients are higher than those in healthy subjects,and the higher the Killip grade of cardiac function is,the higher the levels of serum NT-proBNP and cTnI are,and there are negative correlation between NT-proBNP,cTnI and LVEF in NSTE-ACS patients.

关 键 词：非ST段抬高型急性冠脉综合征 心功能 N末端B型利钠肽原 心肌肌钙蛋白I 

分 类 号：R541.4[医药卫生—心血管疾病]