慢性乙型肝炎肝硬化患者并发肌少症的高危因素分析  

Analysis of High-risk Factors for Sarcopenia in Patients with Chronic Hepatitis B Cirrhosis

作　　者：杨歆[1] 谢霞 窦橙云 唐简[1] YANG Xin;XIE Xia;DOU Chengyun;TANG Jian(Department of Infectious Diseases,First Affiliated Hospital of Nanhua University,Hengyang 421001,China)

机构地区：[1]南华大学附属第一医院感染科,湖南衡阳421001

出　　处：《中国医学创新》2025年第7期155-158,共4页Medical Innovation of China

基　　金：2022年湖南省卫生健康委科研立项课题(202203082548)。

摘　　要：目的:探究慢性乙型肝炎(CHB)肝硬化患者并发肌少症的高危因素。方法:回顾性分析2023年1—12月南华大学附属第一医院收治的103例CHB肝硬化患者的临床资料。均行肌少症检查,依据肌少症发生情况分为两组,收集两组年龄、性别、体重指数(BMI)、肝功能Child-Pugh分级、吸烟史、饮酒史、营养风险、合并高血压、合并糖尿病、高血氨症、合并腹水等临床资料,开展logistic回归分析,获得影响并发肌少症的高危因素。结果:103例患者共出现30例肌少症,发生率为29.13%;发生组BMI<22.5 kg/m^(2)、有营养风险、合并糖尿病、有高血氨症患者占比较未发生组高,差异均有统计学意义(P<0.05);多因素显示,BMI<22.5 kg/m^(2)、有营养风险、合并糖尿病、有高血氨症为影响CHB肝硬化患者并发肌少症的高危因素(P<0.05)。结论:CHB肝硬化患者并发肌少症与BMI<22.5 kg/m^(2)、有营养风险、合并糖尿病、有高血氨症相关,还需高度重视,做好早期防范,以便于降低肌少症发生风险。Objective:To explore the high risk factors of sarcopenia in patients with chronic hepatitis B(CHB)cirrhosis.Method:The clinical data of 103 patients with CHB cirrhosis admitted to the First Affiliated Hospital of Nanhua University from January to December 2023 were retrospectively analyzed.All patients underwent sarcopenia examination and they were divided into two groups according to the occurrence of sarcopenia.Clinical data of the two groups,including age,gender,body mass index(BMI),Child-Pugh classification of liver function,smoking history,drinking history,nutritional risk,combined hypertension,combined diabetes,hyperammonemia and combined ascites were collected and carried out logistic regression analysis.To obtain the high risk factors affecting the complication of sarcopenia.Result:There were 30 cases of sarcopenia in 103 patients,the incidence was 29.13%.The proportion of patients with BMI<22.5 kg/m^(2),nutritional risk,combined diabetes,and hyperammonemia in the occurrence group were higher than those in the non-occurrence group,the differences were statistically significant(P<0.05).Multiple factors showed that BMI<22.5 kg/m^(2),nutritional risk,diabetes mellitus,and hyperammonemia were high risk factors for sarcopenia in patients with CHB cirrhosis(P<0.05).Conclusion:Patients with CHB cirrhosis complicated with sarcopenia are associated with BMI<22.5 kg/m^(2),nutritional risk,diabetes mellitus,and hyperammonemia,which should be attached great importance to early prevention in order to reduce the risk of sarcopenia.

关 键 词：慢性乙型肝炎 肝硬化 肌少症 高危因素 

分 类 号：R51[医药卫生—内科学]