纳米酶修饰植入式微电极对电化学传感性能的提升作用与应用研究  

Nanoenzymes modified implantable microelectrodes for enhanced electrochemical sensing performance

作　　者：阳瀚祺 黄爽 刘静 刘爽杰 刘铮杰 陈家宜 高路康 黄新烁 姚传捷 徐兴元 张晓东[4] 陈惠琄 谢曦 YANG Hanqi;HUANG Shuang;LIU Jing;LIU Shuangjie;LIU Zhengjie;CHEN Jiayi;GAO Lukang;HUANG Xinshuo;YAO Chuanjie;XU Xingyuan;ZHANG Xiaodong;Chen Huixuan;XIE Xi(School of Electronics and Information Technology,Sun Yat-sen University,Guangzhou 510006,China;School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518107,China;The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Medical School of Tianjin University,Tianjin 300072,China)

机构地区：[1]中山大学电子与信息工程学院,广东广州510006 [2]中山大学生物医学工程学院,广东深圳518107 [3]中山大学附属第一医院,广东广州510080 [4]天津大学医学院,天津300072

出　　处：《中山大学学报(自然科学版)(中英文)》2025年第2期94-102,共9页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家重点研发计划(2021YFF1200700);国家自然科学基金(T2225010,32171399,32171456);中国博士后科学基金(2023TQ0386);广东省基础与应用基础研究基金(2023A1515011267,2023A1515111139)。

摘　　要：探究了三种纳米酶(Au_(24)Cd_(1),Au_(24)Er_(1),Au_(25))对银丝微电极(AgME)、金丝微电极(AuME)以及大脑皮层电图微电极(EcoGME)的修饰及检测方法。首先,本文成功将三种不同的纳米金属团簇材料修饰到三种电极的表面。电化学阻抗谱实验表明,纳米酶修饰后的电极在低频区域的交流阻抗显著降低。同时,研究了纳米酶修饰对不同电化学记录的影响。采用循环伏安法、差分脉冲伏安法、方波脉冲伏安法、常规脉冲伏安法和线性扫描伏安法对纳米酶修饰的电极进行测试,探讨不同纳米酶材料、电极基材以及检测方法在神经信号采集中的应用效果。研究成果能为神经科学研究等提供了更加精准、高效的传感选择方案。We investigated the modification of three types of nanoenzymes(Au_(24)Cd_(1),Au_(24)Er_(1),Au_(25))on Ag microelectrodes(AgME),Au microelectrodes(AuME),and electrocorticography microelectrode(EcoGME).In this study,three distinct nanoenzymes were successfully immobilized onto the surfaces of three different electrodes.The electrodes modified with nanoenzymes mitigated the inherently high impedance characteristic of conventional neuroelectrodes.Meanwhile,we investigated the effect of nanoenzymatic modifications on different electrochemical recording methods,including electrochemical impedance spectroscopy,cyclic voltammetry,differential pulse voltammetry,square wave pulse voltammetry,normal pulse voltammetry and linear scanning voltammetry.By investigating the effects of various nanoenzyme materials,electrode substrates,and detection methods in neural signal acquisition applications,the findings provide more precise and efficient sensing options for neuroscience research and clinical practice.

关 键 词：纳米酶 植入式微电极 电化学检测 

分 类 号：O657.1[理学—分析化学] TB383[理学—化学]