Edible prodelphinidins that improve postprandial hyperglycemia were discovered in Chinese bayberry(Myrica rubra Sieb.et Zucc.)fruits  

作　　者：Yi Wang Laiming Zhang Jiaxiong Wu Chengxiao Yu Xingqian Ye Haibo Pan Shiguo Chen 

机构地区：[1]College of Biosystems Engineering and Food Science,National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment,Zhejiang Key Laboratory for Agro-food Processing,Integrated Research Base of Southern Fruit and Vegetable Preservation Technology,Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control,Zhejiang University,Hangzhou 310058,China [2]Ningbo Research Institute,Zhejiang University,Ningbo 315100,China [3]Zhejiang University Zhongyuan Institute,Zhengzhou 450000,China [4]Innovation Center of Yangtze River Delta,Zhejiang University,Jiaxing 314102,China

出　　处：《Food Science and Human Wellness》2025年第3期1008-1016,共9页食品科学与人类健康(英文)

基　　金：supported by grants from the National Key Research and Development Program of China(2022YFF1100204);the National Natural Science Foundation of China(31972088,32001715)。

摘　　要：Plant polyphenols are potential substitutes for clinicalα-glucosidase inhibitors.Our previous studies indicated that prodelphinidins from Chinese bayberry leaves(BLPs)have strongerα-glucosidase inhibitory activity than other common polyphenols,but they have no safe history of consumption.There is a reasonable prospect that prodelphinidins from Chinese bayberry fruits(BFPs)can improve postprandial hyperglycemia,though known active components are only myricetin and cyanidin-3-O-glucoside.Hence,the aim of this study was to analyze structure and hypoglycemic effect of BFPs of“Biqi”(BQPs)and“Dongkui”(DKPs)cultivars,and compare their difference with BLPs.The contents of BQPs and DKPs were(221.73±0.60)and(136.82±4.33)mg epicatechin(EC)equivalents/g dry weight,respectively.The most subunits were epigallocatechin gallate along with a small amount of epigallocatechin,epicatechin gallate and EC connected by B-type linkages and a small portion of A-type linkages with mean polymerization degree of 4.25 and 4.08,respectively.Importantly,BQPs and DKPs wereα-glucosidase inhibitors with half inhibitory concentration of 11.91 and 9.47μg/m L respectively,which were significantly stronger than BLPs.DKPs could also improve postprandial hyperglycemia of normal mice and high fat diet-induced type II diabetic mice.Therefore,edible prodelphinidins,which have stronger hypoglycemic effect than BLPs,were first found in Chinese bayberry fruits.

关 键 词：Chinese bayberry fruit Prodelphinidins Structure Α-GLUCOSIDASE Postprandial hyperglycemia 

分 类 号：S47[农业科学—农业昆虫与害虫防治]