Royal jelly modulates serum lipid metabolism and improves brain lipid profiles in natural aging mice  

作　　者：Lili Chen Li Zhao Gaowei Zhang Zhuozhen Li Huihui Ming Liangliang Qu Fangjian Ning Liping Luo 

机构地区：[1]College of Food and Health,Beijing Technology and Business University,Beijing 100048,China [2]School of Life Science,Jiangxi Science&Technology Normal University,Nanchang 330013,China [3]School of Life Sciences,Nanchang University,Nanchang 330031,China [4]Key Laboratory of Geriatric Nutrition and Health Ministry of Education,Beijing Technology and Business University,Beijing 100048,China

出　　处：《Food Science and Human Wellness》2025年第3期1092-1105,共14页食品科学与人类健康(英文)

基　　金：supported by the Science and Technology Department of Jiangxi Province(20212AEI91010);National Natural Science Foundation of China(31772067);Jiangxi Agriculture Research System(JXARS-14);Research Project of State Key Laboratory of Food Science and Technology(SKFL-ZZB-2)。

摘　　要：Royal jelly(RJ)is rich in various nutrients with multiple health-promoting properties.This study aims to evaluate whether RJ can modulate related metabolite in the natural aging mice.Male C57BL/6J mice drank RJ solution daily for 9 months.Determination of serum lipids and pathological analysis exhibited that triglycerides,serum cholesterol,and low-density lipoprotein cholesterol were decreased by 31.15%,9.96%,and 22.58%,respectively,the morphology of brain nerve cells was also effectively recovered after RJ intervention.Lipidomic analysis showed that RJ could improve the levels of different kinds of lipids in aging mice brain,especially by increasing the content of antioxidant ether ester,and that the ratio of monounsaturated fatty acid to polyunsaturated fatty acid was up by 23.46%,which could alleviate oxidative stress.Moreover,the metabolism of glycerol phospholipids,glycerols,and fatty acids in aging mice could be regulated by RJ.RJ intervention can effectively improve lipid metabolism disorders caused by aging.

关 键 词：Royal jelly Natural aging BRAIN Lipidomic Fatty acids 

分 类 号：R28[医药卫生—中药学]