Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway  

作　　者：Dan Hong Xiao Xiao Aijin Ma Zhou Chen Siting Li Junxia Xia Yiling Tian Yingmin Jia 

机构地区：[1]School of Food and Health,Beijing Technology and Business University,Beijing 100048,China [2]Hebei Yangyuan Zhihui Beverage Co.,Ltd.,Hengshui 053000,China [3]Institution of Chinese Walnut Industry,Hengshui 053000,China [4]Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology,Hengshui 053000,China [5]College of Food Science and Technology,Hebei Agricultural University,Baoding 071000,China

出　　处：《Food Science and Human Wellness》2025年第3期1127-1138,共12页食品科学与人类健康(英文)

基　　金：supported by the National Key Research and Development Program(2022YFD1600402);Hebei Provincial Major Science and Technology Achievement Transformation Project(21287101Z);Hebei Provincial Innovation and Entrepreneurship Team Project(215A7102D)。

摘　　要：Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations.Dietary interventions are being considered as potential strategies for delaying age-related dysfunction.Unsaponifiable matter(USM),a composition of highly active ingredients found in walnut oil,has demonstrated antioxidant effects.This study aims to explore the neuroprotective effects of USM on d-galactose-treated C57BL/6 mice and elucidate its underlying mechanism,which was validated in PC12 cells treated with d-galactose.The results of behavioral tests demonstrated that USM significantly improved cognitive deficits associated with aging.The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage,synaptic impairment,and mitochondrial dysfunction induced by d-galactose.Furthermore,USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde and reactive oxygen species levels.The results suggest that USM can mitigate age-related symptoms caused by d-galactose by activating the nuclear factor erythroid-2-related factor 2 signaling pathway,which enhances the expression of antioxidant enzymes,restore redox balance,and improves synaptic and mitochondrial functions.This has a positive on improving cognition and memory disorders in elderly mice.

关 键 词：Unsaponifiable matter Memory impairment mitochondrial dysfunctions Nrf2 signaling pathway Antioxidant stress 

分 类 号：TB8[一般工业技术—摄影技术]