Goji berry-derived phenylpropionyl phenylethylamine derivatives protect against ethanol-induced hepatic damage  

作　　者：Zhengqun Zhou Zhaodi Che Jiancong Mai Rui Zhang Zhihui Luo Yifang Li Kwokfai So Jia Xiao Xinsheng Yao Hao Gao 

机构地区：[1]Institute of Traditional Chinese Medicine&Natural Products,College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China/Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,Jinan University,Guangzhou 510632,China [2]Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery,the First Affiliated Hospital of Jinan University,Guangzhou 510632,China [3]GMH Institute of CNS Regeneration,Guangdong Medical Key Laboratory of Brain Function and Diseases,Jinan University,Guangzhou 510632,China

出　　处：《Food Science and Human Wellness》2025年第3期1139-1147,共9页食品科学与人类健康(英文)

基　　金：funded via National Natural Science Foundation of China(81925037,82321004,U22A20371,and 82273801);Guangdong Major Project of Basic and Applied Basic Research(2023B0303000026);Guangdong International Science and Technology Cooperation Base(2021A0505020015);Innovative and Research Teams Project of Guangdong Higher Education Institution(2021KCXTD001);Guangdong Basic and Applied Basic Research Foundation(2022A1515012071);Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(2021-QNRC2-B21);Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine(2023LSYS002);Guangzhou Key Laboratory of Traditional Chinese Medicine&Disease Susceptibility(2024A03J090);Science and Technology Program of Guangzhou(201707010414,202201020066,and 2024A04J9955)。

摘　　要：Goji berry is a famous edible and medicinal substance around the world.In this research,15 phenylpropionyl phenylethylamine derivatives(1-15),in cluding one new compound(1),were separated and identified from g oji berry.All isolates were elucidated via ex tensive nuclear magnetic resonance spectral analyses and chemical techniques.Six known isolates were first obtained from Lycium genus.Six isolates were effectively split in to double chromatographic peaks accompanied by the basically identical areas,indicating they belong to racemates.The oxygen radical absorbance capacity(ORAC)experiment indicated that all isolates displayed a capacity of scavenging free radicals,and most of them exhibited higher ORAC than epigallocatechingallate.In ethanol/palmitic acid-established in vitro hepatocyte injury model,four phenylpropionyl phenylethylamine derivatives(1,2,9,and 15)significantly alleviated hepatocyte injury,among which compound 1 exerted the strongest protective activity.Notably,the hepatoprotective effect of compound 1 was further confirmed in ethanol-established liver damage mouse model,reflected by the reduction of lipid accumulation and the attenuation of pathological alteration.Combined with the in vitro results,the in vivo observations suggested that compound 1 suppressed cell apoptosis and the outburst of inflammation.Our findings provided first-hand evidence proving that goji berry-derived phenylpropionyl phenylethylamine derivatives hold a potential in treating alcoholic liver disease.

关 键 词：Goji berry Lycium barbarum Phenylpropionyl phenylethylamine derivatives Antioxidant activity He patoprotective effect 

分 类 号：O62[理学—有机化学]