半乳糖凝集素-3在2型糖尿病及其并发症中的作用机制研究进展  

Research Progress on the Mechanism of Galectin-3 in Type 2 Diabetes and Its Complications

作　　者：何婷 He Ting(Department of Endocrinology,Affiliated Renhe Hospital of China Three Gorges University,The Second Clinical Medical College of China Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学第二临床医学院[三峡大学附属仁和医院]内分泌科,湖北宜昌443000

出　　处：《巴楚医学》2025年第1期124-128,共5页Bachu Medical Journal

基　　金：湖北省卫生健康委员会联合基金项目(WJ2019H548)。

摘　　要：由于我国人口老龄化不断进展及居民生活方式、饮食习惯的改变,2型糖尿病(T2DM)发病率呈逐年增高的趋势,常见的糖尿病并发症有糖尿病合并肾病、神经病变、视网膜病变、心肌病变及血管病变,T2DM及相关并发症的进展对患者的生活质量及预后产生了严重影响。半乳糖凝集素-3(Gal-3)是一种强大的促炎因子,在炎症细胞的激活、趋化和细胞因子释放中发挥重要作用,且与糖代谢异常及相关靶器官受损密切相关。本文就Gal-3在T2DM中的作用机制进行综述,有望为T2DM及其并发症的防治提供新的监测指标及治疗靶点。Due to the continuous progression of population aging and changes in residents'lifestyle and dietary habits in China,the incidence of type 2 diabetes mellitus(T2DM)is increasing year by year.The common complications of T2DM include diabetic nephropathy,neuropathy,retinopathy,cardiomyopathy,and vascular disease.The progression of T2DM and its complications has a severe impact on patients'quality of life and prognosis.Galectin-3(Gal-3)is a potent pro-inflammatory factor that plays a significant role in the activation,chemotaxis,and cytokine release of inflammatory cells,which is closely related to abnormal glucose metabolism and related target organ damage.This article reviews the mechanism of action of Gal-3 in T2DM,with the hope of providing new monitoring indicators and therapeutic targets for the prevention and treatment of T2DM and its complications.

关 键 词：半乳糖凝集素-3 2型糖尿病 糖尿病并发症 

分 类 号：R587.1[医药卫生—内分泌]