老年人带状疱疹与认知功能障碍的相关性研究  

Association between herpes zoster and cognitive impairment among Chinese elderly individuals

作　　者：郑冰冰 曹文婷 张萍 游咏 丁金东 ZHENG Bingbing;CAO Wenting;ZHANG Ping;YOU Yong;DING Jindong(不详;School of Public Health,Hainan Medical University,Haikou 571199,China)

机构地区：[1]海南医科大学公共卫生学院,571199 [2]海南医科大学第二附属医院神经内科,海南医科大学衰老与肿瘤国际研究中心,海南省热带脑科学研究与转化重点实验室,570013

出　　处：《中国神经免疫学和神经病学杂志》2025年第2期100-105,共6页Chinese Journal of Neuroimmunology and Neurology

基　　金：国家自然科学基金(82360673);海南省重点研发项目(ZDYF2024SHFZ064);海南医科大学引进人才科研启动项目(XRC2022005);海南医科大学研究生创新科研课题(HYYB2023A09)。

摘　　要：目的探讨老年人中带状疱疹(herpes zoster,HZ)与认知功能障碍(cognitive impairment,CI)之间的相关性。方法2023年4月至10月采用方便抽样法对海南省海口市8个社区≥60岁的老年人开展横断面调查,共调查937名老年人,年龄(72.12±7.76)岁,其中男386名,女551名。收集被调查者的人口学特征、现病史及HZ患病史,并使用中文版简易智能精神状态检查量表(mini-mental state examination,MMSE)评估认知水平。采用倾向性评分匹配(propensity score matching,PSM)法将认知功能正常组与CI组进行1∶1比例的基本情况匹配。通过多因素Logistic回归分析PSM匹配前后HZ与CI的关联性。结果937名老年人中存在CI 304名(32.4%)。匹配前的多因素Logistic回归分析结果显示,有HZ患病史的老年人其CI的风险是无HZ患病史老年人的1.672倍〔OR(95%CI):1.672(1.039~2.691),P<0.05〕;PSM匹配后,性别构成、婚姻状况、体重指数、高血压、糖尿病和高血脂症等混杂因素在组间平衡,多因素分析结果仍然显示HZ患病史是老年人发生CI的风险因素〔OR(95%CI):2.154(1.125~4.122),P<0.05〕。结论在海口市老年人中,带状疱疹患病史与CI具有相关性。未来的大样本队列研究应进一步验证二者之间的因果关系,为疾病的预防和干预提供科学依据。Objective To investigate the association between herpes zoster(HZ)and cognitive impairment(CI)among elderly individuals.Methods A cross-sectional survey was conducted from April to October 2023 using convenience sampling to enroll 937 elderly aged 60 years or older from 8 communities in Haikou City,Hainan Province,with a mean age of(72.12±7.76)years,including 386 males and 551 females.Participants demographic characteristics,medical history including HZ,and chronic diseases were collected.Cognitive function was assessed using the Chinese version of the mini-mental state examination(MMSE).The propensity score matching(PSM)method was used to match the normal cognitive function group with the CI group at a 1∶1 ratio in terms of basic characteristics.A multivariate logistic regression analysis was conducted to examine the association between HZ and CI before and after PSM matching.Results Among 937 participants,304(32.4%)were identified with CI.Before PSM,multivariate analysis showed that the history of HZ was associated with a 1.672-fold increased risk of CI[OR(95%CI):1.672(1.039-2.691),P<0.05].After PSM,confounding factors including sex,marital status,body mass index,hypertension,diabetes,and hyperlipidemia were balanced between groups.The post-matching multivariable analysis consistently demonstrated that the HZ history was significantly associated with CI[OR(95%CI):2.154(1.125-4.122),P<0.05].Conclusions In the elderly population of Haikou,a history of HZ was associated with CI,further large cohort studies are needed for causation evaluation between these two common diseases,in order to provide scientific basis for effective public health prevention and interventions.

关 键 词：认知功能障碍 带状疱疹 倾向性评分匹配分析 老年人 

分 类 号：R181.2[医药卫生—流行病学] R758.3[医药卫生—公共卫生与预防医学] R754.1