妊娠中晚期子宫、胎盘动脉参数与子痫前期严重程度及妊娠结局的关系探讨  

The correlation of uterine and placental artery parameters with severity of preeclampsia and pregnancy outcome in middle and late stages of pregnancy

作　　者：曲昌华 崔美玉 QU Chang-hua;CUI Mei-yu(Department of Obstetrics and Gynecology,Shandong Qingdao University Affiliated Weihai Municipal Second Hospital,Qingdao 264200,China)

机构地区：[1]山东青岛大学附属威海市立二院妇产科,264200

出　　处：《中国现代药物应用》2025年第5期35-38,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨妊娠中晚期子宫、胎盘动脉参数与子痫前期(PE)严重程度及妊娠结局的关系。方法选取86例PE单胎孕妇,根据PE严重程度分为轻度组(30例)和重度组(56例);另选取同期正常单胎孕妇30例作为对照组。检测并比较三组孕妇子宫动脉血流动力学参数[阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(S)与舒张末期流速(D)的比值(S/D)]及舒张期早期切迹发生情况,采用eFlow技术检测并比较三组孕妇的胎盘三级绒毛动脉显示情况及胎盘三级绒毛动脉计数,比较三组孕妇的妊娠结局。结果对照组的RI、PI、S/D及舒张早期切迹发生率分别为(0.52±0.06)、(0.74±0.13)、(2.01±0.37)、10.00%,轻度组分别为(0.56±0.05)、(0.86±0.15)、(2.42±0.48)、33.33%,重度组分别为(0.61±0.07)、(0.99±0.17)、(2.67±0.57)、57.14%。与对照组比较,轻度组、重度组孕妇的RI、PI、S/D及舒张早期切迹发生率均明显升高(P<0.05);与轻度组比较,重度组孕妇的RI、PI、S/D及舒张早期切迹发生率明显升高(P<0.05)。对照组胎盘三级绒毛动脉显示率、胎盘三级绒毛动脉计数分别为83.33%、(3.52±1.26)个,轻度组分别为60.00%、(2.85±1.23)个,重度组分别为37.50%、(2.21±1.01)个。轻度组、重度组孕妇的胎盘三级绒毛动脉显示率、胎盘三级绒毛动脉计数均明显低于对照组(P<0.05);重度组孕妇的胎盘三级绒毛动脉显示率、胎盘三级绒毛动脉计数均明显低于轻度组(P<0.05)。对照组分娩孕周、新生儿体重、羊水异常率、早产率、剖宫产率、胎儿窘迫率分别为(37.32±2.14)周、(3.09±0.28)kg、6.67%、3.33%、10.00%、3.33%,轻度组分别为(33.85±1.24)周、(2.57±0.31)kg、20.00%、16.67%、26.67%、6.67%,重度组分别为(32.03±1.08)周、(2.15±0.25)kg、41.07%、53.57%、58.93%、25.00%。轻度组、重度组孕妇的分娩孕周、新生儿体重均明显小于对照组,剖宫产均明显高于对照组(P<0.05);重度组孕妇的羊水Objective To explore the correlation of uterine and placental artery parameters with severity of preeclampsia(PE)and pregnancy outcome in middle and late stages of pregnancy.Methods 86 singleton pregnant women with PE were selected.According to the severity of PE,the patients were divided into mild group(30 cases)and severe group(56 cases).Another 30 normal singleton pregnant women in the same period were selected as the control group.Detection and comparison of the uterine artery blood flow parameters[resistance index(RI),pulsatility index(PI),and systolic/diastolic velocity ratio(S/D)],and occurrence of early diastolic notch of the three groups;eFlow technology was used to detect and compare the display and count of placental tertiary villous arteries of the three groups,and the pregnancy outcome of the three groups was compared.Results RI,PI,S/D and incidences of early diastolic notch of control group were(0.52±0.06),(0.74±0.13),(2.01±0.37)and 10.00%,those of mild group were(0.56±0.05),(0.86±0.15),(2.42±0.48)and 33.33%,and those of severe group were(0.61±0.07),(0.99±0.17),(2.67±0.57)and 57.14%.Compared with control group,RI,PI,S/D and incidences of early diastolic notch were significantly increased in mild group and severe group(P<0.05).Compared with mild group,RI,PI,S/D and incidences of early diastolic notch in severe group was significantly increased(P<0.05).The display rate and count of placental tertiary villous arteries of control group were 83.33%and(3.52±1.26),those of mild group were 60.00%and(2.85±1.23),and those of severe group were 37.50%and(2.21±1.01).The display rate and count of placental tertiary villous arteries in mild group and severe group were significantly lower than those in control group(P<0.05);the display rate and count of placental tertiary villous arteries in severe group were significantly lower than those in mild group(P<0.05).In control group,the gestational week of delivery,neonatal weight,rate of abnormal amniotic fluid,rate of premature birth,rate of cesarean secti

关 键 词：子宫动脉 胎盘动脉参数 子痫前期 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]