糖化血红蛋白联合OGTT在妊娠期糖尿病中的诊断效能评价  

Evaluation of diagnostic efficacy of glycated hemoglobin combined with OGTT in gestational diabetes mellitus

作　　者：朴学哲 PIAO Xue-zhe(Department of Medical Laboratory,Heilongjiang Red Cross Sengong General Hospital,Harbin 150040,China)

机构地区：[1]黑龙江省红十字(森工总)医院医学检验科,150040

出　　处：《中国现代药物应用》2025年第5期56-59,共4页Chinese Journal of Modern Drug Application

摘　　要：目的评价妊娠期糖尿病(GDM)诊断中采用口服葡萄糖耐量试验(OGTT)联合糖化血红蛋白(HbA1c)检测的诊断效能。方法选取47例健康孕妇(参照组)和47例妊娠期糖尿病孕妇(观察组)为研究对象,均予以OGTT及糖化血红蛋白检测。对比两组血糖指标(空腹血糖、服糖后1 h血糖、服糖后2 h血糖、糖化血红蛋白)水平,OGTT与糖化血红蛋白阳性检出率,分析OGTT与糖化血红蛋白联合检测对妊娠期糖尿病的诊断效能。结果观察组空腹血糖、服糖后1 h血糖、服糖后2 h血糖、糖化血红蛋白水平分别为(9.07±0.34)mmol/L、(14.07±2.62)mmol/L、(12.67±2.46)mmol/L、(10.74±0.58)%,均高于参照组的(4.52±0.46)mmol/L、(5.02±0.33)mmol/L、(4.63±0.83)mmol/L、(5.16±0.77)%,差异有统计学意义(P<0.05)。观察组OGTT、糖化血红蛋白阳性检出率分别为85.11%、93.62%,显著高于参照组的2.13%、6.38%,差异有统计学意义(P<0.05)。OGTT与糖化血红蛋白联合检测诊断妊娠期糖尿病的敏感性、特异性、准确性、阳性预测值、阴性预测值分别为95.74%(45/47)、91.49%(43/47)、93.62%(88/94)、91.84%(45/49)、95.56%(43/45)。结论联合应用OGTT、糖化血红蛋白检测诊断妊娠期糖尿病具有显著效果,不仅诊断准确性高,且能够清晰、明确地反映妊娠期糖尿病孕妇机体血糖水平。Objective To evaluate the diagnostic efficacy of glycated hemoglobin(HbA1c)combined with oral glucose tolerance test(OGTT)in gestational diabetes mellitus(GDM).Methods 47 healthy pregnant women(reference group)and 47 pregnant women with gestational diabetes mellitus(observation group)were selected as the study subjects,and were subjected to OGTT and glycated hemoglobin tests.The blood glucose levels(fasting blood glucose,blood glucose at 1 h after taking sugar,blood glucose at 2 h after taking sugar,glycated hemoglobin)and the positive detection rate of OGTT and glycated hemoglobin were compared between the two groups,and the diagnostic efficacy of OGTT and glycated hemoglobin combined detection was analyzed.Results The levels of fasting blood glucose,blood glucose at 1 h after taking sugar,blood glucose at 2 h after taking sugar and glycated hemoglobin were(9.07±0.34)mmol/L,(14.07±2.62)mmol/L,(12.67±2.46)mmol/L and(10.74±0.58)%in the observation group,which were higher than(4.52±0.46)mmol/L,(5.02±0.33)mmol/L,(4.63±0.83)mmol/L and(5.16±0.77)%in the reference group,and the difference was statistically significant(P<0.05).The positive rates of OGTT and glycated hemoglobin in the observation group were 85.11%and 93.62%,which were significantly higher than 2.13%and 6.38%in the reference group,and the difference was statistically significant(P<0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of OGTT combined with glycated hemoglobin in the diagnosis of gestational diabetes mellitus were 95.74%(45/47),91.49%(43/47),93.62%(88/94),91.84%(45/49)and 95.56%(43/45).Conclusion The combined detection of OGTT and glycated hemoglobin has a significant effect in the diagnosis of gestational diabetes mellitus,which not only has high diagnostic accuracy,but also can clearly reflect the blood glucose level of women with gestational diabetes mellitus.

关 键 词：妊娠期糖尿病 糖化血红蛋白 口服葡萄糖耐量试验 

分 类 号：R58[医药卫生—内分泌]