高血压患者采用缬沙坦氨氯地平治疗的临床效果分析  

Clinical effect analysis of valsartan and amlodipine in patients with hypertension

作　　者：于海燕 YU Hai-yan(Department of Pharmacy,Zibo Radio and Television Hospital,Zibo 255000,China)

机构地区：[1]淄博广电医院药剂科,255000

出　　处：《中国现代药物应用》2025年第5期79-82,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究高血压患者采用缬沙坦氨氯地平治疗的临床效果。方法166例高血压患者,采用随机数字表法分为观察组、对照组,各83例。观察组实施缬沙坦氨氯地平治疗,对照组实施苯磺酸左氨氯地平治疗。对比两组治疗前后颈动脉内膜中层厚度(IMT)、治疗效果、血压变异性、血管紧张素Ⅱ水平及不良反应发生情况。结果治疗后,两组IMT均小于治疗前,且观察组IMT(0.83±0.01)mm小于对照组的(0.99±0.13)mm(P<0.05)。观察组治疗总有效率97.59%高于对照组的78.31%(P<0.05)。治疗后,两组24 h平均舒张压、24 h平均收缩压、24 h舒张压变异系数、24 h收缩压变异系数均低于治疗前,且观察组24 h平均舒张压(75.14±2.01)mm Hg(1 mm Hg=0.133 kPa)、24 h平均收缩压(139.52±3.11)mm Hg、24 h舒张压变异系数(10.05±1.58)%、24 h收缩压变异系数(13.06±1.10)%均低于对照组的(81.36±2.78)mm Hg、(145.85±4.45)mm Hg、(11.98±1.78)%、(15.22±1.88)%(P<0.05)。治疗后,两组血管紧张素Ⅱ水平均低于治疗前,且观察组血管紧张素Ⅱ(31.02±1.85)ng/L低于对照组(37.52±1.97)ng/L(P<0.05)。观察组不良反应发生率(2.41%)低于对照组(20.48%)(P<0.05)。结论缬沙坦氨氯地平治疗高血压效果显著、安全性高,可有效降低血压及血管紧张素Ⅱ水平,值得推广。Objective To explore the clinical effect of valsartan and amlodipine in patients with hypertension.Methods 166 patients with hypertension were divided into an observation group and a control group by random numerical table,with 83 cases in each group.The observation group was treated with valsartan and amlodipine,while the control group was treated with levamlodipine besylate.The intima-media thickness(IMT)before and after treatment,therapeutic effect,blood pressure variability,angiotensinⅡlevel and adverse reactions were compared between the two groups.Results After treatment,IMT in both groups was lower than that before treatment,and the observation group had a lower IMT of(0.83±0.01)mm than(0.99±0.13)mm in the control group(P<0.05).The total effective rate of 97.59%in the observation group was higher than 78.31%in the control group(P<0.05).After treatment,the 24-h mean diastolic blood pressure,24-h mean systolic blood pressure,24-h diastolic blood pressure-coefficient of variation,24-h systolic blood pressure-coefficient of variation in both groups were lower than those before treatment;in the observation group,the 24-h mean diastolic blood pressure was(75.14±2.01)mm Hg(1 mm Hg=0.133 kPa),the 24-h mean systolic blood pressure was(139.52±3.11)mm Hg,the 24-h diastolic blood pressure-coefficient of variation was(10.05±1.58)%,and 24-h systolic blood pressure-coefficient of variation was(13.06±1.10)%,which were were lower than(81.36±2.78)mm Hg,(145.85±4.45)mm Hg,(11.98±1.78)%,and(15.22±1.88)%in the control group(P<0.05).After treatment,the angiotensinⅡlevel in both groups were lower than that before treatment,and the observation group had a lower angiotensinⅡof(31.02±1.85)ng/L than(37.52±1.97)ng/L in the control group(P<0.05).The incidence of adverse reactions in the observation group(2.41%)was lower than that in the control group(20.48%)(P<0.05).Conclusion Valsartan and amlodipine are effective and safe in the treatment of hypertension,and can effectively reduce blood pressure and angiotensin Ⅱ

关 键 词：高血压 缬沙坦氨氯地平 血压变异性 血管紧张素Ⅱ 

分 类 号：R544.1[医药卫生—心血管疾病]