伊可新治疗小儿维生素D缺乏性佝偻病的临床有效性分析  

Analysis of the clinical effectiveness of vitamin A and D drops in the treatment of vitamin D deficiency rickets in children

作　　者：徐攀 张雪梅[1] XU Pan;ZHANG Xue-mei(Department of Pediatrics,Zibo Maternal and Child Health Hospital,Zibo 255000,China)

机构地区：[1]淄博市妇幼保健院儿科,255000

出　　处：《中国现代药物应用》2025年第5期93-95,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究维生素AD滴剂(胶囊型)(商品名:伊可新)治疗小儿维生素D缺乏性佝偻病的有效性。方法选择维生素D缺乏性佝偻病患儿100例,按随机数字表法分为研究组、对照组,每组50例。对照组给予鱼肝油滴剂+钙剂治疗,研究组给予伊可新+钙剂治疗。比较两组血清生化指标[钙离子(Ca^(2+))、25-羟基维生素D3[25-(OH)D3]、骨碱性磷酸酶(BALP)]、体格指标、骨密度水平及不良反应发生率。结果治疗后,研究组患儿Ca^(2+)(2.49±0.35)mmol/L、25-(OH)D3(63.27±1.36)ng/ml、BALP(284.26±16.15)U/L均高于对照组的(2.26±0.21)mmol/L、(44.37±1.42)ng/ml、(141.57±15.22)U/L(P<0.05)。治疗后,研究组患儿身高(106.38±1.13)cm、体重(20.17±0.30)kg、BMI(9.22±2.52)kg/m^(2)均高于对照组的(97.23±1.22)cm、(15.88±1.28)kg、(7.79±1.61)kg/m^(2)(P<0.05)。治疗后,研究组患儿尺骨、桡骨骨密度分别为(0.53±0.15)、(0.54±0.15)g/cm^(2),均高于对照组的(0.43±0.10)、(0.44±0.11)g/cm^(2)(P<0.05)。研究组不良反应发生率2.00%低于对照组的18.00%(P<0.05)。结论小儿维生素D缺乏性佝偻病治疗中运用伊可新,可改善患儿血清生化指标、体格指标以及骨密度水平,降低不良反应发生率,建议进一步推广运用。Objective To study the effectiveness of vitamin A and D drops(soft capsule container)in the treatment of vitamin D deficiency rickets in children.Methods 100 children with vitamin D deficiency rickets were selected and divided into study group and control group according to random numerical table,with 50 cases in each group.The control group was treated with cod-liver oil drops and calcium,and the study group was treated with vitamin A and D drops and calcium.Both groups were compared in terms of serum biochemical indexes[calcium ion(Ca^(2+)),25-hydroxyvitamin D3[25-(OH)D3],bone alkaline phosphatase(BALP)],physical indicators,bone mineral density and incidence of adverse reactions.Results After treatment,the study group had Ca^(2+)of(2.49±0.35)mmol/L,25-(OH)D3 of(63.27±1.36)ng/ml and BALP of(284.26±16.15)U/L,which were higher than(2.26±0.21)mmol/L,(44.37±1.42)ng/ml and(141.57±15.22)U/L in the control group(P<0.05).After treatment,the study group had height of(106.38±1.13)cm,body weight of(20.17±0.30)kg and BMI of(9.22±2.52)kg/m^(2),which were higher than(97.23±1.22)cm,(15.88±1.28)kg and(7.79±1.61)kg/m^(2)in the control group(P<0.05).After treatment,the bone mineral densities of ulna and radius in the study group were(0.53±0.15)and(0.54±0.15)g/cm^(2),which were higher than(0.43±0.10)and(0.44±0.11)g/cm^(2)in the control group(P<0.05).The incidence of adverse reactions(2.00%)in the study group was lower than that in the control group(18.00%)(P<0.05).Conclusion The use of vitamin A and D drops in the treatment of children with vitamin D deficiency rickets can improve the serum biochemical indexes,physical indexes and bone mineral density of children,and reduce the incidence of adverse reactions.

关 键 词：维生素AD滴剂(胶囊型) 小儿 维生素D缺乏性佝偻病 血清生化指标 体格指标 骨密度 

分 类 号：R723.2[医药卫生—儿科]