补阳还五汤合四妙散治疗出血性中风后并发CMVT的效果分析  

Effect analysis of Buyang Huanwu decoction and Simiao powder in the treatment of CMVT after hemorrhagic stroke

作　　者：马阳 侯志峰[3] 李耀文 MA Yang;HOU Zhi-feng;LI Yao-wen(Graduate School of Anhui University of Traditional Chinese Medicine,Hefei 230038,China)

机构地区：[1]安徽中医药大学研究生院,230038 [2]宿州市第一人民医院康复医学科,234000 [3]安徽中医药大学第一附属医院脑病科,230031 [4]合肥工业大学医院,230009

出　　处：《中国现代药物应用》2025年第5期119-122,共4页Chinese Journal of Modern Drug Application

基　　金：2023年度安徽省卫生健康科研项目计划(项目编号:AHWJ2023A20281)。

摘　　要：目的探讨补阳还五汤合四妙散治疗出血性中风后并发小腿肌间静脉血栓(CMVT)的效果。方法40例出血性中风并发CMVT患者,按照随机数字表法分为对照组和观察组,各20例。对照组采用常规治疗,观察组在对照组的基础上口服补阳还五汤合四妙散治疗。比较两组的治疗效果及凝血指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、D-二聚体(D-D)、纤维蛋白原(FIB)]。结果治疗2周后,两组的总有效率比较,差异无统计学意义(P>0.05)。治疗4周后,观察组的总有效率90.00%高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗2周后,两组的PT、APTT、TT、D-D、FIB比较,差异无统计学意义(P>0.05);治疗4周后,两组的PT、APTT、TT比较,差异无统计学意义(P>0.05),观察组的D-D(1.39±1.63)mg/L、FIB(2.49±0.80)g/L低于对照组的(2.78±1.15)mg/L、(3.14±0.79)g/L,差异均有统计学意义(P<0.05)。结论使用补阳还五汤合四妙散可以有效改善出血性中风后并发CMVT患者的治疗效果,对患者的凝血功能有积极影响。Objective To explore the effect of Buyang Huanwu decoction and Simiao powder in the treatment of calf muscular venous thrombosis(CMVT)after hemorrhagic stroke.Methods A total of 40 patients with CMVT after hemorrhagic stroke were divided into control group and observation group according to the random number table method,each with 20 cases.The control group received conventional therapy,and the observation group was treated with Buyang Huanwu decoction and Simiao powder on the basis of the control group.Both groups were compared in terms of therapeutic effect and coagulation indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),D-dimer(D-D),fibrinogen(FIB)].Results After 2 weeks of treatment,there was no statistically significant difference in the total effective rate between the two groups(P>0.05).After 4 weeks of treatment,the total effective rate of 90.00%in the observation group was higher than 60.00%in the control group,and the difference was statistically significant(P<0.05).After 2 weeks of treatment,there was no statistically significant difference in PT,APTT,TT,D-D and FIB between the two groups(P>0.05).After 4 weeks of treatment,there was no statistically significant difference in PT,APTT,and TT between the two groups(P>0.05).The observation group had D-D of(1.39±1.63)mg/L and FIB of(2.49±0.80)g/L,which were lower than(2.78±1.15)mg/L and(3.14±0.79)g/L in the control group,and the differences were statistically significant(P<0.05).Conclusion The use of Buyang Huanwu decoction and Simiao powder can effectively improve the treatment effect of patients with CMVT after hemorrhagic stroke,and has an active effect on the coagulation function of patients.

关 键 词：出血性中风 补阳还五汤合四妙散 小腿肌间静脉血栓 

分 类 号：R255.2[医药卫生—中医内科学]