四君子汤加减治疗对慢性萎缩性胃炎患者不良反应的影响研究  

Study on the effect of modified Sijunzi Decoction on adverse reactions in patients with chronic atrophic gastritis

作　　者：司席席 SI Xi-xi(Yanggu County People's Hospital,Liaocheng 252300,China)

机构地区：[1]阳谷县人民医院,252300

出　　处：《中国现代药物应用》2025年第5期136-139,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析针对慢性萎缩性胃炎(CAG)患者应用四君子汤加减治疗的临床效果及对不良反应的影响。方法80例CAG患者,采用红蓝信封法分为参比组(40例,西药治疗)与分析组(40例,西药治疗+四君子汤加减治疗)。比较两组中医证候积分、胃黏膜前列腺素E2(PGE2)及炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)]水平、不良反应发生率及幽门螺杆菌(Hp)转阴率。结果治疗后,两组胃脘疼痛、大便稀溏、反酸、胃脘胀满积分均低于治疗前,且分析组胃脘疼痛、大便稀溏、反酸、胃脘胀满积分分别为(0.93±0.23)、(0.70±0.44)、(0.89±0.36)、(0.84±0.45)分,均低于参比组的(1.64±0.65)、(0.93±0.23)、(1.18±0.38)、(1.43±0.51)分,参数差异成立(P<0.05)。治疗后,两组胃黏膜PGE2及TNF-α、IL-8水平均优于治疗前,且分析组PGE2(281.85±29.71)pg/ml高于参比组的(241.52±24.14)pg/ml,TNF-α(38.64±5.40)pg/ml、IL-8(6.41±0.65)pg/ml低于参比组的(44.52±6.93)、(8.31±1.52)pg/ml,参数差异成立(P<0.05)。分析组不良反应发生率2.50%低于参比组的15.00%,参数差异成立(P<0.05)。分析组Hp转阴率为95.00%(38/40),高于参比组的80.00%(32/40),参数差异成立(P<0.05)。结论针对CAG患者,应用四君子汤加减治疗,既可缓解中医证候,抑制炎性反应,还可提升内源性胃保护因子表达,降低不良反应发生率,可推广。Objective To analyze the clinical effect of modified Sijunzi Decoction in patients with chronic atrophic gastritis(CAG)and its influence on adverse reactions.Methods 80 patients with CAG were divided into reference group(40 cases,Western medicine treatment)and analysis group(40 cases,Western medicine treatment+modified Sijunzi Decoction)by red and blue envelope method.Both groups were compared in terms of traditional Chinese medicine syndrome score,gastric mucosal prostaglandin E2(PGE2)and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)]levels,incidence of adverse reactions and rate of negative conversion of Helicobacter pylori(Hp).Methods After treatment,the scores of epigastric pain,loose stool,acid reflux and epigastric fullness in both groups were lower than those before treatment;in the analysis group,the scores of epigastric pain,loose stool,acid reflux and epigastric fullness were(0.93±0.23),(0.70±0.44),(0.89±0.36)and(0.84±0.45)points,which were lower than(1.64±0.65),(0.93±0.23),(1.18±0.38)and(1.43±0.51)points in the reference group;the parameter difference was established(P<0.05).After treatment,the levels of PGE2,TNF-αand IL-8 in gastric mucosa in both groups were better than those before treatment;the analysis group had a higher PGE2 of(281.85±29.71)pg/ml than(241.52±24.14)pg/ml in the reference group;the analysis group had TNF-αof(38.64±5.40)pg/ml and IL-8 of(6.41±0.65)pg/ml,which were lower than(44.52±6.93)and(8.31±1.52)pg/ml in the reference group;the parameter difference was established(P<0.05).The incidence of adverse reactions in the analysis group(2.50%)was lower than that in the reference group(15.00%),and the parameter difference was established(P<0.05).The rate of negative conversion of Hp in the analysis group was 95.00%(38/40),which was higher than 80.00%(32/40)in the reference group,and the parameter difference was established(P<0.05).Conclusion For CAG patients,the application of modified Sijunzi Decoction can not only relieve traditional Chinese m

关 键 词：四君子汤 慢性萎缩性胃炎 不良反应 胃保护因子 中医证候 

分 类 号：R25[医药卫生—中医内科学]