不同膨体聚四氟乙烯不可吸收缝合线的性能研究  

The Study on Performance of Different Expanded Polytetrafluoroethylene NonAbsorbable Sutures

作　　者：吴海明 谢琦宗 张再 张杰 李冠桦 黄桥 周昭霖 Wu Haiming;Xie Qizong;Zhang Zai;Zhang Jie;Li Guanhua;Huang Qiao;Zhou Zhaolin(Halocinch Medical Technology(Shenzhen)Co.,Ltd.,ShenzhenGuangdong 518057,China;Conlife Medical Technology(Shenzhen)Co.,Ltd.,ShenzhenGuangdong 518057,China)

机构地区：[1]瀚芯医疗科技(深圳)有限公司,广东深圳518057 [2]聚辉医疗科技(深圳)有限公司,广东深圳518057

出　　处：《医疗装备》2025年第3期7-12,共6页Medical Equipment

摘　　要：人工腱索在人体心脏内会长期经受应力及内皮细胞爬覆影响。人工腱索通常由具有良好生物相容性和力学性能的合成材料制成,为确保人工腱索的安全性及有效性,选择合适的人工腱索缝合材料尤为重要。目前,临床常用的人工腱索材料为柔软、表面光滑的膨体聚四氟乙烯(ePTFE),但不同ePTFE不可吸收缝合线的性能仍有差异。该研究测试了GORE CV-4、GORE CV-5及ZEUS 2-0三种不同ePTFE不可吸收缝合线的理化性能。结果发现,GORE CV-4的ePTFE不可吸收缝合线的抗张强度较好,进行循环拉伸后,其具有更小的延伸量及弹性模量,能在心脏内长时间维持其结构和功能;同时,GORE CV-4的ePTFE不可吸收缝合线具有较大孔径和较高的孔隙率,有利于组织内皮细胞爬覆。Artificial tendons are subjected to stress and endothelial cell crawling effects in the human heart for a long time.Artificial tendons are usually made of synthetic materials with good biocompatibility and mechanical properties.Therefore,in order to ensure the safety and effectiveness of artificial tendons,it is particularly important to select the appropriate suture material for artificial tendons.Currently,with the common use of soft and smooth-surfaced expanded polytetrafluoroethylene(ePTFE)as a material for artificial tendons in clinical practice,the performance of different ePTFE non-absorbable sutures is still different.In this study,the physicochemical properties of three different ePTFE nonabsorbable sutures were tested.It was found that the ePTFE non-absorbable suture of CV-4 had good tensile strength;After cyclic stretching,with smaller elongation and elastic modulus,it was better able to maintain its structure and function in the heart for a long time;At the same time,with larger pore size and higher porosity,the non-absorbable sutures of ePTFE in CV-4 were more conducive to the crawling of endothelial cells.

关 键 词：人工腱索 膨体聚四氟乙烯 抗张强度 孔隙率 延伸量 弹性模量 

分 类 号：R318[医药卫生—生物医学工程]