还少丹联合太极拳对轻度认知障碍患者症状的改善作用及机理研究  

Study on the Improvement Effect of Huanshao Dan Combined with Tai Chi on Symptoms in Patients with Mild Cognitive Impairment and Its Mechanism

作　　者：李其琪 费禹哲 陆莉 李茂全 Li Qiqi;Fei Yuzhe;Lu Li;Li Maoquan(School of Public Health,Chengdu Medical College,Chengdu 610500,China;Sichuan Provincial Key Laboratory of Philosophy and Social Sciences for Smart Healthcare and Elderly Health Management,Chengdu 610500,China;Chengdu Eighth People's Hospital,Chengdu 610000,China;Chengdu Qingbaijiang District Traditional Chinese Medicine Hospital,Chengdu 610300,China;Neijiang Health Vocational College,Neijiang 641100,China)

机构地区：[1]成都医学院公共卫生学院,成都610500 [2]智慧医养与老年健康管理四川省哲学社会科学重点实验室,成都610500 [3]成都市第八人民医院,成都610000 [4]成都市青白江区中医医院,成都610300 [5]内江卫生与健康职业学院,内江641100

出　　处：《成都医学院学报》2025年第2期327-330,共4页Journal of Chengdu Medical College

基　　金：四川省中医药管理局基金项目(No:2024MS147,No:2023MS097);智慧医养与老年健康管理四川省哲学社会科学重点实验室开放基金资助(No:ZHYYZKZD2401)。

摘　　要：目的探讨还少丹联合太极拳干预对轻度认知障碍(MCI)患者症状的改善作用。方法采用自身前后对照的方法,选择2022年1-12月成都市第八人民医院住院的MCI患者31例,实施12周还少丹联合太极拳干预。采用蒙特利尔认知评估量表(MoCA)测量患者的认知功能;匹兹堡睡眠质量量表(PSQI)测定睡眠质量;单分子超灵敏蛋白质检测技术(SIMOA)分析血浆Aβ40、Aβ42、神经胶质纤维酸性蛋白(GFAP)和神经丝蛋白轻链(NFL)的含量;酶联免疫吸附法(ELISA)分析血清脑源性神经营养因子(BDNF)及鸢尾素含量。结果干预12周后,MoCA评分提高,PSQI评分降低,血浆Aβ40、NFL水平下降,血清BDNF及鸢尾素水平上升(P<0.05)。结论还少丹联合太极拳干预能改善MCI患者认知功能和睡眠质量,降低血浆Aβ40及NFL含量,其作用机制可能与提高血清BDNF及鸢尾素的水平有关。Objective To explore the effect of Huanshao Dan combined with Tai Chi intervention on the improvement of symptoms in patients with mild cognitive impairment(MCI)and its mechanism.Methods A total of 31 patients with MCI admitted to Chengdu Eighth People's Hospital from January 2022 to December 2022 were included in the self-comparison study involving a 12-week intervention of Huanshao Dan combined with Tai Chi.Montreal Cognitive Assessment(MoCA)was used to measure patients'cognitive function.Pittsburgh Sleep Quality Index(PSQI)was utilized to assess patients'sleep quality.Single-Molecule Array(SIMOA)was used to analyze the plasma levels of Aβ40,Aβ42,glial fibrillary acidic protein(GFAP)and neurofilament light(NFL).Enzyme-Linked Immunosorbent Assay(ELISA)was employed to assess the serum levels of brain-derived neurotrophic factor(BDNF)and irisin.Results After 12 weeks of intervention,the MoCA score increased,the PSQI score decreased,plasma Aβ40 and NFL levels decreased,and serum BDNF and irisin levels increased(P<0.05).Conclusion The intervention of Huanshao Dan combined with Tai Chi can improve cognitive function and sleep quality,and reduce plasma Aβ40 and NFL levels in patients with MCI.The mechanism of action may be related to the increase of serum BDNF and irisin levels.

关 键 词：太极拳 还少丹 轻度认知障碍 鸢尾素 脑源性神经营养因子 

分 类 号：R277.7[医药卫生—中医学] R248.9R749.1