1990-2021年中国生殖道沙眼衣原体感染的疾病负担趋势  

The disease burden of genital Chlamydia trachomatis infection in China from 1990 to 2021

作　　者：杨韵青 叶鹏鹏 唐卫明[5] 郑晓静 林确然 赵伟佳 杨海慧 叶兴东 罗权 李畅畅 YANG Yunqing;YE Pengpeng;TANG Weiming;ZHENG Xiaojing;LIN Queran;ZHAO Weijia;YANG Haihui;YE Xingdong;LUO Quan;LI Changchang(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China;Guangzhou Dermatology Hospital,Guangzhou 510095,China;Southern Medical University Institute for Global Health,Guangzhou 510091,China;Division of Injury Prevention and Mental Health,National Center for Chronic and Noncommunicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102200,China;University of North Carolina at Chapel Hill,North Carolina 27516,USA;Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091 [2]广州市皮肤病医院,广东广州510095 [3]南方医科大学全球健康研究院,广东广州510091 [4]中国疾病预防控制中心慢性非传染性疾病预防控制中心,北京102200 [5]北卡罗来纳大学教堂山分校,北卡罗来纳州27516 [6]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《皮肤性病诊疗学杂志》2025年第2期115-123,共9页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：国家自然科学基金(72304129);广州市卫生健康委一般引导项目(20241A011069)。

摘　　要：目的阐明1990—2021年我国生殖道沙眼衣原体(CT)感染的疾病负担现状及时间变化趋势,为优化我国生殖道CT感染防控策略提供依据。方法利用2021年全球疾病负担研究(GBD2021)数据,描述全国生殖道CT感染发病、患病和伤残调整寿命年(DALYs)现况,采用对数线性回归模型计算平均年度变化百分比(AAPC)分析时间趋势,采用广义线性模型探索区域经济水平对疾病负担趋势的关联。结果2021年,我国估计生殖道CT感染新发病例数约6267万例,发病率4405.16/10万(标化发病率为4163.33/10万);现患病例约3874万例,患病率2722.86/10万(标化患病率为2563.92/10万);因生殖道CT感染导致的DALYs数为2.598万人年,DALYs率1.83/10万(标化DALYs率1.70/10万)。1990—2021年间,发病率和患病率稳定,DALYs呈下降趋势[AAPC=-0.32%,(95%CI:-0.45%,-0.19%)]。2021年,男性发病率和DALYs率高于女性,女性患病率高于男性。1990—2021年间,男性疾病负担均下降,女性发病率和患病率上升、DALYs率下降。2021年,全人群疾病负担在30~34岁达到峰值,除女性DALYs率在40~44岁最高外,其余指标男女疾病负担峰值年龄与全人群一致;西部省份的年龄标化发病率最高,中部最低。1990—2021年间,年龄标化发病率和年龄标化患病率增长速度最快的是山西省,年龄标化DALYs率增长无统计学意义。2020—2021年,人均GDP与标化发病率、标化DALYs率呈U型关联。结论我国生殖道CT感染疾病负担虽然稳中有降,但整体仍处于高水平。未来我国应结合区域经济活动特征、人群风险等级分级分类制定防控策略实现精准防控,尤其需关注25~34岁人群。Objective To clarify the burden of genital Chlamydia trachomatis(CT)infection in China and its temporal trend.Methods Using data from the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2021,we assessed the incidence,prevalence,and disability-adjusted life years(DALYs)of genital CT infection in 2021 in national-and provincial-level.The joinpoint regression was used to analyze the temporal trends of the above three types of burdens associated with disease from 1990 to 2021.Additionally,the GDP per capita as a cubic spline into a generalized linear model was used to explore the influence of economic status on the incidence,prevalence,and DALYs rates of age-standardized genital CT infection.Results In 2021,there were a total of 62.67 million new cases of genital CT infection in China,with an incidence rate of 4405.16 per 100000 population(age-standardized:4163.33 per 100000).The cases were around 38.74 million,with a prevalence of 2722.86 per 100000 population(age-standardized:2563.92 per 100000).The disability-adjusted life years(DALYs)due to genital CT infection were 25980 person-years,with a DALYs rate of 1.83 per 100000(age-standardized:1.70 per 100000).The incidence rates and prevalence were stable,while DALYs had a declining trend[average annual percent change(AAPC):-0.32%,(95%CI:-0.45%~-0.19%)]between 1990 and 2021.Incidence rates and DALYs were higher in males than in females,whereas prevalence was higher in females than in males in 2021.From 1990 to 2021,the disease burden was decreased in males,while incidence rates and prevalence were increased in females,but DALYs were decreased.In 2021,the overall disease burden peaked at ages of 30-34.Except for the peak of DALYs in females at age 40-44 years,the disease burden peaked in age ranges consistent with the general population in both genders.The age-standardized incidence rates were the highest in western provinces and lowest in central provinces.From 1990 to 2021,Shanxi showed the fastest growth in age-standardized incidence rates and prevalen

关 键 词：沙眼衣原体感染 生殖道 发病率 患病率 伤残调整寿命年 疾病负担 

分 类 号：R691.3[医药卫生—泌尿科学]