液-液相分离在动脉粥样硬化中的关键作用  

The key role of liquid-liquid phase separation in atherosclerosis

作　　者：赵方尧 李俊豪 杨科 杨洪军[1] ZHAO Fangyao;LI Junhao;YANG Ke;YANG Hongjun(Experiment Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Life Sciences,China Jiliang University,Hangzhou,Zhejiang 310018,China)

机构地区：[1]中国中医科学院医学实验中心,北京市100700 [2]中国计量大学生命科学学院,浙江省杭州市310018

出　　处：《中国动脉硬化杂志》2025年第3期185-193,201,共10页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金青年科学基金项目(81803761);中央本级重大增减支项目·名贵中药资源可持续利用能力建设项目(2060302)。

摘　　要：液-液相分离是细胞内生物分子凝聚形成无膜细胞器的重要过程,在细胞信号传导和基因表达调控等方面发挥着重要作用。研究表明液-液相分离可能参与动脉粥样硬化的发生与发展,并在疾病的诊断和治疗中具有潜在应用价值。该文介绍了液-液相分离的概念和机制,深入探讨了液-液相分离与动脉粥样硬化的关系,总结了液-液相分离在动脉粥样硬化研究中的进展,并展望了其应用前景。Liquid-liquid phase separation is an important process in which intracellular biomolecules condense to form membraneless organelles,playing a significant role in cell signaling and gene expression regulation.Studies have shown that liquid-liquid phase separation may be involved in the occurrence and development of atherosclerosis and has potential applications in the diagnosis and treatment of the disease.This article introduces the concept and mechanism of liquid-liquid phase separation,delves into the relationship between liquid-liquid phase separation and atherosclerosis,summarizes the progress of liquid-liquid phase separation in atherosclerosis research,and looks forward to its application prospects.

关 键 词：液-液相分离 动脉粥样硬化 研究进展 应用前景 

分 类 号：R5[医药卫生—内科学]