肠道菌群影响代谢性疾病血管钙化的研究进展  

Advances in the influence of the gut microbiota on metabolic disease-related vascular calcification

作　　者：陈倩[1] 唐子淇 丁银元 CHEN Qian;TANG Ziqi;DING Yinyuan(Centre for Lipid Research&Chongqing Key Laboratory of Metabolism on Lipid and Glucose,Chongqing Medical University,Chongqing 400016)

机构地区：[1]重庆医科大学脂质研究中心脂糖代谢性疾病重庆市重点实验室,重庆市400016

出　　处：《中国动脉硬化杂志》2025年第3期194-201,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82270854);重庆市自然科学基金项目(cstc2020jcyj-msxmX0408)。

摘　　要：肠道菌群参与调节宿主免疫、消化、肠道内分泌系统功能,且通过代谢产物影响宿主神经信号传导及营养物质代谢。血管钙化是指磷酸钙在血管壁沉积,可继发于慢性肾病、动脉粥样硬化、糖尿病及骨质疏松症等代谢性疾病。近二十年研究结果表明,肠道菌群的组成和功能改变及其代谢产物与上述代谢性疾病血管钙化的发生存在密切联系。文章针对肠道菌群的作用及其机制进行综述。The gut microbiome actively regulates host immunity,digestive processes,and the function of the intestinal endocrine system.Additionally,it modulates host neural signal transmission and nutrient metabolism through metabolite generation.Vascular calcification involves the deposition of calcium phosphate in blood vessel walls,secondary to metabolic disorders such as chronic kidney disease,atherosclerosis,diabetes,and osteoporosis.Recent research spanning the past two decades has indicated a close correlation between shifts in the composition and functionality of the gut microbiota,along with its metabolites,and the onset of metabolic disease-related vascular calcification.This paper presents a comprehensive review of the roles and mechanisms of the gut microbiota in this context.

关 键 词：肠道菌群 血管钙化 慢性肾病 动脉粥样硬化 糖尿病 骨质疏松症 

分 类 号：R5[医药卫生—内科学]