2018-2022年吉林省肺结核合并糖尿病患者治疗转归情况及影响因素分析  

Analysis of treatment outcomes and influencing factors of patients with pulmonary tuberculosis complicated with diabetes mellitus in Jilin Province,2018-2022

作　　者：安源 白云龙 赵庆龙 马建军 姜雪 潘艳 高迎 高智慧 An Yuan;Bai Yunlong;Zhao Qinglong;Ma Jianjun;Jiang Xue;Pan Yan;Gao Ying;Gao Zhihui(Department of Tuberculosis Prevention and Control,Jilin Scientific Research Institute of Tuberculosis Prevention and Control(Affiliated Hospital of Jilin Scientific Research Institute of Tuberculosis Prevention and Control),Changchun 130103,China;Dean’s Office,Jilin Scientific Research Institute of Tuberculosis Prevention and Control,Changchun 130103,China;Department of Diagnosis and Treatment Quality Evaluation,Jilin Scientific Research Institute of Tuberculosis Prevention and Control,Changchun 130103,China;Department of Multidrug-resistant Tuberculosis Prevention and Control,Jilin Scientific Research Institute of Tuberculosis Prevention and Control,Changchun 130103,China;Department of Epidemic Monitoring,Jilin Scientific Research Institute of Tuberculosis Prevention and Control,Changchun 130103,China)

机构地区：[1]吉林省结核病防治科学研究院(吉林省结核病防治科学研究院附属医院)结核病预防控制所,长春130103 [2]吉林省结核病防治科学研究院院长办公室,长春130103 [3]吉林省结核病防治科学研究院诊疗质量评价所,长春130103 [4]吉林省结核病防治科学研究院耐多药防治指导所,长春130103 [5]吉林省结核病防治科学研究院疫情监测所,长春130103

出　　处：《中国防痨杂志》2025年第4期432-438,共7页Chinese Journal of Antituberculosis

摘　　要：目的:分析2018—2022年吉林省肺结核合并糖尿病患者治疗转归及影响因素,为完善肺结核合并糖尿病防控策略提供依据。方法:通过“中国疾病预防控制信息系统”子系统“结核病信息管理系统”收集2018—2022年吉林省肺结核患者病案信息,采用描述性方法分析肺结核合并糖尿病患者特征及治疗转归情况,采用二元logistic回归分析其治疗转归的影响因素。结果:2018—2022年吉林省共登记肺结核合并糖尿病患者2640例,占全人群肺结核患者的5.67%(2640/46594),从2018年的3.45%(468/13569)上升至2022年的9.10%(573/6296),呈逐年上升趋势(χ^(2)_(趋势)=302.583,P<0.05)。肺结核合并糖尿病患者以男性(79.02%,2086/2640)、45~64岁患者(61.36%,1620/2640)、病原学阳性(77.61%,2049/2640)为主。全省肺结核合并糖尿病患者成功治疗率为89.37%(2119/2371),不良结局发生率为10.63%(252/2371)。多因素logistic回归分析结果显示,≥65岁年龄组(OR=1.573,95%CI:1.009~2.452),病原学阳性(OR=1.471,95%CI:1.029~2.104),复治(OR=2.311,95%CI:1.565~3.412),流动人口(OR=4.745,95%CI:3.359~6.704)是肺结核合并糖尿病患者发生不良结局的危险因素。结论:吉林省肺结核合并糖尿病患者治疗情况总体欠佳,应重点关注≥65岁老年人、病原学阳性、复治、流动人口等肺结核合并糖尿病患者。Objective:To analyze treatment outcomes and influencing factors of patients with pulmonary tuberculosis complicated with diabetes mellitus(PTB-DM)in Jilin Province from 2018 to 2022,and to provide a basis for improving PTB-DM prevention and control strategy.Methods:Data of PTB patients in Jilin Province from 2018 to 2022 were collected through the Tuberculosis Management Information System of the China Disease Control and Prevention Information System.Characteristics and treatment outcomes of PTB-DM patients were analyzed using descriptive methods.Binary logistic regression model was used to analyze influencing factors of treatment outcomes.Results:From 2018 to 2022,a total of 2640 PTB-DM patients were registered in Jilin Province,accounting for 5.67%(2640/46594)of the total population of PTB patients,which increased from 3.45%(468/13569)in 2018 to 9.10%(573/6296)in 2022,showing a yearly increasing trend(χ^(2)_(trend)=302.583,P<0.05).PTB-DM patients were mainly male(79.02%,2086/2640),45 to 64 years old(61.36%,1620/2640),etiologically positive(77.61%,2049/2640).The treatment success rate of PTB-DM patients in the province was 89.37%(2119/2371),and the adverse outcome incidence was 10.63%(252/2371).Multivariable logistic regression analysis showed that age group of≥65 years(OR=1.573,95%CI:1.009-2.452),etiologically positive(OR=1.471,95%CI:1.029-2.104),receiving retreatment(OR=2.311,95%CI:1.565-3.412),floating population(OR=4.745,95%CI:3.359-6.704)were risk factors for adverse outcomes in PTB-DM patients.Conclusion:The treatment outcomes of PTB-DM patients in Jilin Province are generally poor,so more attention should be paid to PTB-DM patients over 65 years old,etiologically positive,receiving retreatment,and floating population.

关 键 词：结核 肺 糖尿病 治疗结果 因素分析 统计学 

分 类 号：R521[医药卫生—内科学] R587.1[医药卫生—临床医学]