基于文献计量学的结核病中医药基础研究全球研究现状及热点分析  

Bibliometric analysis of global research status and hotspots in the basic research of Traditional Chinese Medicine for tuberculosis

作　　者：尚希钰 张慧芳 曹玉清 熊一白 纪鑫毓 田雅欣 李佳佳 王倪[3] 马艳 Shang Xiyu;Zhang Huifang;Cao Yuqing;Xiong Yibai;Ji Xinyu;Tian Yaxin;Li Jiajia;Wang Ni;Ma Yan(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;National Center for Tuberculosis Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国中医科学院中药研究所,北京100700 [3]中国疾病预防控制中心结核病预防控制中心,北京102206

出　　处：《中国防痨杂志》2025年第4期482-497,共16页Chinese Journal of Antituberculosis

基　　金：国家重点研发计划(2023YFC3503400);国家自然科学基金(82274350)。

摘　　要：目的:探讨结核病的中医药基础研究全球研究现状与趋势。方法:检索中国知识资源总库、万方数据库、PubMed和Web of Science等4个数据库收录的与中医药防治结核病基础研究相关的中英文文献,检索时间截至2024年6月30日。使用CiteSpace和VOSviewer软件分别对中英文文献的发文量、作者及机构分布、关键词、中药使用频率等进行可视化分析。结果:共纳入文献140篇,涉及190家机构的546位作者,其中中文文献102篇(72.86%),英文文献38篇(27.14%)。最早的文献发表于1961年,自1993年起,论文发文量呈现上升趋势。在文献期刊分布方面,发表中文文献最多的期刊为《中国防痨杂志》(6.86%,7/102),发表英文文献最多的期刊为Journal of Ethnopharmacology(10.53%,4/38)。作者合作网络方面,中文文献形成了以“王莉新、王易”和以“潘建华、石国民、向延根、喻容”为核心的研究团队,英文文献形成了以“Jiang Xin、Sun Jinxia、Zheng Yuejuan”为核心的研究团队;机构合作网络形成了以“上海中医药大学”和“长治医学院”为核心的科研合作机构。中英文关键词聚类共形成了16个聚类,提示该领域研究热点主要集中于抗菌作用、免疫调节等。夏枯草、猫爪草、百部、大黄、大蒜是关注度最高的单味中药,黄芩苷、猫爪草提取物、大蒜素、姜黄素是关注度最高的中药成分或中药提取物,白及-百部是中药复方中关联最强的药对。结论:结核病的中医药基础研究近年来引起国内外较多关注,中医药抗菌作用及免疫调节机制可能会成为未来的研究热点。未来应深入开展多部门跨领域之间的合作,为阐明中医药防治结核病的作用机制与诊疗规律提供依据。Objective:To explore the global research status and trends in basic research on Traditional Chinese Medicine(TCM)for prevention and treatment of tuberculosis(TB).Methods:We conducted a comprehensive literature review of Chinese and English publications related to basic TCM research against TB using Chinese national knowledge infrastructure,Wanfang database,PubMed and Web of Science database with a cutoff date of June 30,2024.Bibliometric analysis was performed using CiteSpace and VOSviewer software to visualize publication metrics,author and institution networks,keywords clusters and the frequency of TCM interventions in both Chinese and English literature.Results:A total of 140 articles were included,contributed by 546 authors from 190 institutions,including 102 Chinese articles(72.86%)and 38 English articles(27.14%).The first publication appeared in 1961,with a noticeable increase in research output observed since 1993.In terms of journal distribution,the journal with the most Chinese publications was Chinese Journal of Antituberculosis(6.86%,7/102),and the journal with the most English publications was Journal of Ethnopharmacology(10.53%,4/38).Regarding author collaboration networks,the Chinese literature formed two research terms centered around“Wang Lixin and Wang Yi”,“Pan Jianhua,Shi Guomin,Xiang Yangen,Yu Rong”,respectively,while the English literature formed research teams centered around“Jiang Xin,Sun Jinxia,Zheng Yuejuan”.The institution collaboration network centered around“Shanghai University of Traditional Chinese Medicine”and“Changzhi Medical College.”Keyword clustering analysis in both Chinese and English literature revealed 16 distinct clusters,with research hotspots primarily concentrating on antibacterial effects and immunomodulation.Additionally,Prunella vulgaris,Radix Ranunculi Ternati,Radix stemonae,Rhubarb,Garlic were the most concerned single herb;baicalin,Radix Ranuncoli Ternati extracts,Allicin and Curcumin were the most TCM ingredients or extracts;while the combinatio

关 键 词：结核 医学 中国传统 基础研究 文献计量学 

分 类 号：R52[医药卫生—内科学] R285.5[医药卫生—临床医学]