肺结核与肠道菌群的相关性及治疗策略  

Association between pulmonary tuberculosis and the gut microbiota:treatment strategies

作　　者：李敏 姚宇珊 乔海霞 雷红 Li Min;Yao Yushan;Qiao Haixia;Lei Hong(School of Graduate Studies,Hebei North University,Zhangjiakou 075000,China;Department of Clinical Laboratory,the Eighth Medical Center,General Hospital of the Chinese People’s Liberation Army,Beijing 100091,China)

机构地区：[1]河北北方学院研究生学院,张家口075000 [2]中国人民解放军总医院第八医学中心检验科,北京100091

出　　处：《中国防痨杂志》2025年第4期520-526,共7页Chinese Journal of Antituberculosis

基　　金：解放军总医院第八医学中心院级研究课题计划(MS202211004)。

摘　　要：肺结核是常见的呼吸道传染疾病,近年来,越来越多的研究表明肠道菌群与肺结核之间存在密切相关性。肠道菌群能够通过肠-肺轴的联系介导肺结核的免疫进程,而肺结核的感染也会引起肠道菌群的生态失衡。笔者总结了结核分枝杆菌感染与肠道菌群之间的相互关联、肠道菌群在肺结核免疫中的作用机制,以及微生物疗法在肺结核治疗中的应用潜力,以期为肺结核的治疗提供新策略。Tuberculosis(TB)remains a prevalent respiratory infectious disease worldwide.In recent years,accumulating evidence has highlighted a strong association between the gut microbiota and TB pathogenesis.The gut microbiota plays a critical role in modulating TB immunity through the gut-lung axis,while TB infection itself can induce significant dysbiosis in the intestinal microbial ecosystem.This review explores the bidirectional interplay between Mycobacterium tuberculosis(MTB)infection and the gut microbiota,elucidates the immunological mechanisms underlying their interaction,and discusses the therapeutic potential of microbiome-based interventions for TB.These insights may contribute to the development of novel treatment strategies for TB management.

关 键 词：结核 肺 肠杆菌科 免疫系统 

分 类 号：R521[医药卫生—内科学] R37[医药卫生—临床医学]