抑郁症动物模型的建立及评价方法研究进展  

Development of an animal model of depression and evaluation methods

作　　者：刘子轩 霍清[1] 孙雅煊 戴雪伶 李昕[1] LIU Zixuan;HUO Qing;SUN Yaxuan;DAI Xueling;LI Xin(College of Biochemical Engineering,Beijing Union University,Beijing 100191,China)

机构地区：[1]北京联合大学生物化学工程学院,北京100191

出　　处：《中国实验动物学报》2025年第2期249-258,共10页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(11975048);北京联合大学校级科研项目(ZK10202204),北京联合大学校级教改项目(JY2023Y008)。

摘　　要：抑郁症是一种常见的慢性精神疾病,抑郁症动物模型被广泛应用于抑郁症发病机制的研究和抗抑郁新药的研发,其模拟人类抑郁症状的同一性和可靠性会直接影响研究结果。然而,目前还尚未发现与人类抑郁症发病完全契合的动物模型,阻碍了对抑郁症的深入研究。然而通过采用科学、合理的造模和评价方法,能够在较大程度上模拟抑郁症的病理状态,为深入理解抑郁症的发病机制和进一步研发有效的抗抑郁药物提供基础。本文旨在通过综述几种常用的动物抑郁模型及行为测试方法,为研究者提供参考。Depression is a common chronic mental illness.Animal models of depression are widely used to study the pathogenesis of depression as well as in the development of new antidepressant drugs.The consistency and reliability of animal models of depression to simulate human depressive symptoms directly affect the study result.However,at present,no animal models have been found that are completely consistent with the onset of human depression,which hinders the in⁃depth study of depression.By using scientific and reasonable modeling and evaluation method,the pathological state of depression can still be simulated to a large extent,providing a basis for further in⁃depth research of the pathogenesis of depression and the development of effective antidepressant drugs.This paper aims to provide a reference for researchers by reviewing several commonly used animal models and behavioral tests of depression.

关 键 词：抑郁症 动物模型 发病机制 

分 类 号：Q95-33[生物学—动物学]