cAMP信号通路在抑郁症发病机制及干预策略中的研究进展  

Research progress on cAMP signaling pathway in the pathogenesis and intervention strategies of depression

作　　者：刘京霞 陈新旺[1] 郭娅静[1] 董永书 郭昱辰 LIU Jingxia;CHEN Xinwang;GUO Yajing;DONG Yongshu;GUO Yuchen(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Henan Province Integrated Traditional Chinese and Western Medicine Hospital,Zhengzhou 450004,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南省中西医结合医院,郑州450004

出　　处：《中国实验动物学报》2025年第2期267-274,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然基金青年基金项目(81704183);2023年河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-7-11);河南省中医药拔尖人才培养项目资助(豫卫中医函[2023]2号)。

摘　　要：抑郁症是目前普遍存在的一种精神类疾病,给患者生活质量带来负面影响的同时,也给社会带来严重的经济负担。近年来,基于信号传导通路来干预抑郁症的策略引起社会广泛关注,其中cAMP通路作为一个重要的细胞信号通路,在抑郁症的发病机制和干预过程中起着关键作用。因此,就近年来有关基于cAMP通路干预抑郁症的研究进行综述,为调控cAMP通路及其级联影响抑郁症的作用机制提供理论依据。Depression is a common mental illness that has a negative impact on patient quality of life,as well as representing a serious economic burden to society.The strategy of interfering with depression based on signaling pathways has recently attracted widespread attention.The cAMP pathway is an important cellular signaling pathway that plays a key role in the pathogenesis of and interventions for depression.In this review,we addresses recent studies on cAMP pathway⁃based interventions in depression,to provide a theoretical basis for regulating the cAMP pathway and its cascade mechanism in depression.

关 键 词：抑郁症 cAMP通路 PKA CREB BDNF 信号通路 

分 类 号：Q95-33[生物学—动物学]