模式生物斑马鱼作为抑郁模型的研究进展  

Progress of research into the zebrafish(Danio rerio)depression model

作　　者：郭碧玉 杨惠栾 陈依凡 杨晓密 姚政 毛羽 GUO Biyu;YANG Huiluan;CHEN Yifan;YANG Xiaomi;YAO Zheng;MAO Yu(Basic Medicine College,Yunnan University of Chinese Medicine,Kunming 650500,China;Yunnan Key Laboratory of Chronic Disease Prevention and Treatment of Integrated Traditional Chinese and Western Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学基础医学院,昆明650500 [2]云南省中西医结合慢病防治重点实验室,昆明650500

出　　处：《中国实验动物学报》2025年第2期275-287,共13页Acta Laboratorium Animalis Scientia Sinica

基　　金：云南省科技厅中医基础研究联合专项(202001AZ0001-040)。

摘　　要：斑马鱼具有繁殖周期短、发育早期(胚)体呈透明、与人类遗传和生理高度同源性及养殖成本低等优点,对哺乳动物抑郁症模型的局限性具有一定的弥补作用,目前已成为研究精神类疾病的一种最有潜力的模式生物。由于斑马鱼独特的生物学特性和模型建立方法的多样性,利用斑马鱼建立抑郁症模型开展的研究正处于快速发展阶段。本文旨在从斑马鱼抑郁模型的造模方法、评价指标、优势与局限性等方面进行全面综述。The zebrafish is characterized by its rapid reproductive cycle,transparent embryonic body in the early developmental stages,high genetic and physiological homology with humans,and low breeding costs.These advantages make it a valuable tool that complements mammalian models of depression.The zebrafish has emerged as a promising model organism for studying mental illnesses owing to its unique biological characteristics and the diverse method available for establishing depression models using this species.This article aims to provide a comprehensive review of zebrafish depression model establishment method,evaluation criteria,advantages,and limitations.

关 键 词：斑马鱼 抑郁症 疾病动物模型 

分 类 号：Q95-33[生物学—动物学]