阿尔茨海默病病证结合动物模型的研究进展  

Research progress of Alzheimer’s disease syndromes combined with animal models

作　　者：李丽 严兴科 魏玉婷 窦婷婷 LI Li;YAN Xingke;WEI Yuting;DOU Tingting(College of Acupuncture-Moxibustion and Tuina,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Research Center of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学针灸推拿学院,兰州730000 [2]甘肃省中医药研究中心,兰州730000

出　　处：《中国实验动物学报》2025年第2期296-310,共15页Acta Laboratorium Animalis Scientia Sinica

基　　金：甘肃省中医药研究中心2024年度专项开放课题(zyzx-2024-zx03);2023年甘肃省省级重点人才项目(甘组通字[2023]20号);2024年高校教师创新基金项目(2024A-082)。

摘　　要：阿尔茨海默病(Alzheimer’s disease, AD)是一种常见的神经退行性疾病,中医药治疗AD效果良好,病证结合动物模型是开展相关研究的基础。本文整理和归纳常用非转基因型AD动物模型及AD病证结合动物模型的研究资料,发现当前常见的非转基因型AD动物模型包括老化型(自然老化型、快速老化型和诱导老化型)和注入诱导损伤型(Aβ注射动物模型、Tau蛋白损伤型、胆碱能系统损伤模型、神经炎症模型和铝中毒诱导模型)共八种,AD病证结合动物模型有肾虚/肾虚精亏/肾虚髓空、痰浊阻窍、瘀血阻络、痰瘀互结、肝郁和痰饮郁热证六种。本文通过综述各模型复制方法的优势及不足,以期为今后AD病证结合动物模型的研究提供参考。Alzheimer’s disease(AD)is a common neurodegenerative disease.Traditional Chinese medicine is effective in treating AD.The combination of disease and syndrome with animal model is the basis and premise of related research.In this paper,studies on non⁃transgenic AD animal models and AD disease and syndrome combined animal models are summarized.It was found that,there are eight common non⁃transgenic AD animal models,including aging type(natural aging type,rapid aging type and induced aging type)and injection⁃induced injury type(Aβinjection animal model,Tau damage type,damage model of cholinergic system,neuroinflammatory model and aluminum poisoning induction model).AD disease and syndrome combined with animal models include kidney deficiency/kidney deficiency and essence deficiency/kidney deficiency and pulp emptying,phlegm turbidity blocking orifice,blood stasis blocking collaterals,phlegm stasis interlocking,liver depression and phlegm fluid stagnation heat.In this paper,the advantages and disadvantages of each model replication method are reviewed,in order to provide reference and support for the future study of AD disease and syndrome combined with animal models.

关 键 词：阿尔茨海默病 动物模型 病证结合 研究进展 

分 类 号：Q95-33[生物学—动物学]