南京某医院新确诊梅毒患者111例合并淋球菌、沙眼衣原体及人乳头瘤病毒感染分析  

Analysis of Neisseria gonorrhoeae, Chlamydia trachomatis and human papillomavirus coinfections in 111 patients with newly diagnosed syphilis at a hospital in Nanjing

作　　者：赵诗轩 赵园园 乐文静 王碧伟 陈雅丽 甘璐 李赛 朱小凤 苏晓红 Zhao Shixuang;Zhao Yuanyuan;Le Wenjing;Wang Biwei;Chen Yali;Gan Lu;Li Sai;Zhu Xiaofen;Su Xiaohong(STD Clinic,Hospital of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院、北京协和医学院皮肤病医院性病科,南京210042

出　　处：《中华皮肤科杂志》2025年第3期234-238,共5页Chinese Journal of Dermatology

基　　金：中国医学科学院医学与健康科技创新工程项目(CIFMS-2021-I2M-1-001)。

摘　　要：目的评估南京某医院新确诊梅毒患者合并淋球菌(NG)、沙眼衣原体(CT)及高危人乳头瘤病毒(HPV)感染率及相关影响因素。方法对2023年5月到2024年4月就诊于中国医学科学院皮肤病医院性病科新确诊的梅毒患者进行横断面研究,根据患者性别及性行为方式采集尿道拭子、宫颈拭子或直肠拭子进行CT、NG及高危HPV核酸检测,其中高危HPV检测仅在女性患者中进行。对CT感染的相关危险因素进行单因素分析,根据样本量及期望值选用卡方检验、连续校正卡方检验或Fisher精确检验。结果收集到有检测标本的确诊新发梅毒患者111例,男71例(64%),女40例(36%),年龄16~87岁;早期梅毒82例,晚期隐性梅毒29例;近3个月性伴数0~3个。男性早期梅毒60例,合并NG感染1例(1.7%),CT感染12例(20%);16例MSM中7例(43.8%)感染CT,44例异性恋患者中5例(11.4%)感染CT,两组间CT感染率差异有统计学意义(χ2=5.80,P=0.016)。女性早期梅毒22例,合并NG感染1例(4.5%),CT感染8例(36.4%);<25岁的12例患者中8例(66.7%)CT阳性,25~44岁7例和≥45岁3例患者无CT感染,3个年龄组CT感染率差异有统计学意义(P=0.005);近3个月性伴数1个的16例中有3例和性伴数2~3个的6例中有5例CT阳性,两组间CT感染率差异有统计学意义(P=0.011)。女性梅毒患者40例,合并高危HPV感染16例(40%),其中年龄<25岁的14例中8例阳性,25~44岁的9例中2例阳性,≥45岁的17例中6例阳性,3个年龄组间差异无统计学意义(P=0.265)。结论新确诊早期梅毒患者中CT感染率较高;<25岁的女性梅毒患者高危HPV感染率较高。Objective To investigate the prevalence of and risk factors associated with Neisseria gonorrhoeae(NG),Chlamydia trachomatis(CT)and high-risk human papillomavirus(HPV)coinfections among patients with newly diagnosed syphilis at a hospital in Nanjing.Methods A cross-sectional study was conducted on patients with newly diagnosed syphilis at the STD Clinic,Hospital of Dermatology,Chinese Academy of Medical Sciences in Nanjing,China from May 2023 to April 2024.Urethral,cervical or rectal swabs were collected according to the gender and types of sexual behavior of the patients.Screening tests for CT,NG and HPV infections were then performed by nucleic acid amplification testing.High-risk HPV testing was performed only in female patients.Univariate analysis was carried out to investigate risk factors associated with CT infection.The chi-square test,chi-square test with continuity correction,or Fisher's exact test was chosen based on the sample size and expected values.Results A total of 111 newly diagnosed syphilis patients with test specimens were collected,including 71 males(64%)and 40 females(36%),and their ages ranged from 16 to 87 years;there were 82 patients with early syphilis and 29 with late latent syphilis;the number of sexual partners in the past 3 months ranged from 0 to 3.Among the 60 male patients with early syphilis,1(1.7%)was co-infected with NG,and 12(20%)with CT;among the 16 men who have sex with men,7(43.8%)were co-infected with CT,while 5(11.4%)of the 44 heterosexual patients were co-infected with CT,showing a significant difference in CT infection rates between the two groups(χ2=5.80,P=0.016).Among the 22 female patients with early syphilis,1(4.5%)was co-infected with NG,and 8(36.4%)with CT;among the 12 female patients aged<25 years,8(66.7%)were infected with CT,while none of the 7 patients aged 25-44 years or the 3 patients aged≥45 years were infected with CT,showing a significant difference in CT infection rates among the 3 age groups(P=0.005);among the 16 female patients with 1 sexual partner

关 键 词：梅毒 淋病奈瑟球菌 沙眼衣原体 α乳头状瘤病毒属 同时感染 

分 类 号：R75[医药卫生—皮肤病学与性病学]