不同年龄小型猪听觉失匹配负波的波形特征分析  

Characteristics of Auditory Mismatch Negativity in Miniature Pigs at Different Ages

作　　者：唐菲 杨崇灵 郭维维[2] 吕萍[1] 刘军[2,3] TANG Fei;YANG Chongling;GUO Weiwei;LÜPin;LIU Jun(Department of Otolaryngology Head and Neck Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;不详)

机构地区：[1]川北医学院川北医学院附属医院耳鼻咽喉头颈外科,南充637000 [2]中国人民解放军总医院耳鼻咽喉头颈外科医学部,听觉与平衡觉全国重点实验室,国家耳鼻咽喉疾病临床医学研究中心,聋病教育部重点实验室,聋病防治北京市重点实验室 [3]中国人民解放军总医院第七医学中心耳鼻咽喉头颈外科

出　　处：《中华耳科学杂志》2025年第2期256-260,共5页Chinese Journal of Otology

基　　金：国家自然科学基金项目(82371148)。

摘　　要：目的分析不同年龄小型猪听觉失匹配负波(mismatch negativity,MMN)的波形特征,探讨小型猪在听觉中枢发育及功能研究中的作用。方法选取3月龄和6月龄正常听力小型猪,各6头(12耳),应用Smart EP听觉诱发电位系统,在麻醉状态下采用经典Oddball刺激范式行听觉MMN检测,采集听觉MMN波形,记录并分析潜伏期及振幅,借助SPSS 25.0软件进行统计分析。结果12头(24耳)小型猪中,11头(22耳)引出典型的听觉MMN波形,检出率为91.67%,平均潜伏期为(230.73±42.90)ms,平均振幅为(3.28±2.28)μV;3月龄组听觉MMN潜伏期为(266.10±20.22)ms,6月龄组潜伏期为(201.25±33.08)ms,差异有统计学意义(P<0.01);两组之间振幅差异无明显统计学意义(P>0.05)。结论小型猪听觉MMN波形、潜伏期范围及发育趋势与人类相似,可作为听觉中枢发育及功能研究的实验动物模型。Objective To report characteristics of mismatch negativity(MMN)in miniature pigs of different ages and discuss their roles in research on central auditory development and function.Methods Auditory MMN tests were performed using the classic Oddball stimulus paradigm on a Smart EP auditory evoked potential system in 3 and 6-month-old normal-hearing male miniature pigs(6[12 ears]each)under anesthesia.The latency and amplitude were analyzed using the SPSS 25.0 software.Results Eleven of the 12 miniature pigs(22 ears,91.67%)exhibited typical auditory MMN waveforms.The average latency was 230.73±42.90 ms,266.10±20.22 ms in the 3-month-old group and 201.25±33.08 ms in the 6-month-old group(P<0.01).The mean amplitude was 3.28±2.28μV with no significant difference between the two age groups(P>0.05).Conclusion Auditory MMN waveforms,latency and developmental trend in miniature pigs are similar to those in humans,suggesting that miniature pigs can serve as an appropriate animal model for studying central auditory development and function.

关 键 词：失匹配负波 小型猪 听觉中枢 发育 潜伏期 振幅 

分 类 号：R764[医药卫生—耳鼻咽喉科]