模式识别受体在中耳炎免疫反应中的研究进展  

Advances of Pattern Recognition Receptor in Immune Responses in Otitis Media

作　　者：陈荧荧 刘洋 郑体花[2] 张肖林[1] 赵洪春[1] CHEN Yingying;LIU Yang;ZHENG Tihua;ZHANG Xiaolin;ZHAO Hongchun(Department of Otolaryngology Head and Neck Surgery,Binzhou Medical University Affiliated Hospital,College of Special Education and Rehabilitation,Binzhou Medical University,Binzhou 256603,China;不详)

机构地区：[1]滨州医学院附属医院耳鼻咽喉头颈外科,滨州256603 [2]滨州医学院特殊教育与康复学院

出　　处：《中华耳科学杂志》2025年第2期277-282,共6页Chinese Journal of Otology

基　　金：山东省自然科学基金(ZR2019PH062)。

摘　　要：中耳炎(otitis media,OM)有着高流行率和高发病率,目前已经成为全球的重大医疗负担。先天性免疫系统是中耳内第一道防线,主要通过细胞上模式识别受体(pattern recognition receptors,PRRs)对入侵病原体上的病原体相关分子模式(pathogen-associated molecular patterns,PAMPs)做出反应而激活免疫反应。文章针对PRRs在OM发生中的作用机制进行回顾并综述,以期为临床预防和治疗OM提供理论依据和新的方向。Otitis media(OM)is associated with a high prevalence and a high incidence,and is a major global medical burden.Innate immune system,a key first line of defense in the middle ear,is activated primarily by pattern recognition receptors(PRRs)in response to pathogen-associated molecular patterns(PAMPs)on invading pathogens to cause an inflammatory response.This review examines the role of PRRs in OM pathogenesis,aiming to provide a theoretical foundation and new directions for the prevention and treatment of OM.

关 键 词：中耳炎 模式识别受体 先天性免疫反应 发病机制 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]